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γ/δ Receptor-expressing T-cell clones from a cutaneous T-cell lymphoma suppress hematopoiesis (1992)

Wilhelm, M. ; Meyer, P. ; Batram, C. ; [et al.]

Springer

Annals of hematology 65 (1992), S. 111-115

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ISSN: 1432-0584

Keywords: Interferon-γ ; Hematopoiesis ; γ/δ ; γ/δ T cells ; Cutaneous T-cell lymphoma

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Recently we described a cutaneous T-cell lymphoma expressing the γ/δ T-cell receptor [5]. The patient suffering from this lymphoma showed low numbers of myeloid and T cells in peripheral blood, while B and NK cells were relatively increased. In vitro culture of the patient's bone marrow (BM) cells revealed a significant suppression of myeloid/monocyte colony formation (GM-CFU) compared with normal controls. This was not due to infiltration of the BM with lymphoma cells. We speculated that a soluble factor either secreted or induced by the lymphoma cells might be responsible for the marked suppression of hematopoiesis in this patient. From a skin biopsy with infiltrating γ/δ T-lymphoma cells we established T-cell clones bearing the γ/δ T-cell receptor and resembling the phenotype of the lymphoma cells. The supernatant (SN) of these γ/δ T-cell clones reduced the number of colonies in a CFU-GM assay (using normal control BM) in comparison to SN of α/β T-cell clones established from the same biopsy. This suppression was seen mainly on day 7 of culture and was not neutralized by the addition of placenta-CM. The main mediator of this suppression seems to be IFN-γ,since it was detectable in high amounts in the SN of these γ/δ T-cell tumor clones as well as in the serum of the patient. In addition, anti-IFN-γ antibodies can reverse the T-cell SN-mediated suppression of CFU-GM. We conclude that high serum levels of interferon-γ, which is secreted in high amounts from γ/δ T-cells grown from a biopsy of a cutaneous lymphoma, can suppress hematopoiesis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01695808

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Application of the finite element method to the simulation of sheet forming processes: Comparison of calculations and experiments (1990)

Keck, P. ; Wilhelm, M. ; Lange, K.

Chichester [u.a.] : Wiley-Blackwell

International Journal for Numerical Methods in Engineering 30 (1990), S. 1415-1430

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ISSN: 0029-5981

Keywords: Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics , Technology

Notes: Elastic-plastic finite element calculations have been carried out to analyse sheet forming processes such as hydrostatic bulging of circular and rectangular blanks and the axisymmetric stretching of sheets (with different punch radii). The results, partly obtained by different finite element models, are compared with experimental data. It could be shown that, regarding the examples considered, experiments and calculations fit well and that a more sophisticated modelling of the contact boundary conditions improves the accuracy of the results. As a first attempt to handle more complex sheet forming operations, the deep drawing of a rectangular cup has been analysed. A summary of the theoretical background as well as some comments on the solution method and the implementation are given.

Additional Material: 15 Ill.