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  • 1990-1994  (4)
  • Fibromyalgia  (2)
  • superparamagnetic particles  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of opsonins on the uptake of magnetic starch microspheres by rat Kupffer cells (1994)
    Springer
    Magnetic resonance materials in physics, biology and medicine 2 (1994), S. 303-305 
    Details
    ISSN: 1352-8661
    Keywords: MRI contrast agents ; superparamagnetic particles ; opsonins ; perfused liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract The influence of various sera and proteins on the uptake of a superparamagnetic colloid (magnetic starch microspheres (MSM); particle size, 200 nm; crystal size, 10 nm) by the isolated and perfused rat liver has been studied. It is demonstrated that the capture of MSM is slightly reduced by the addition of rat blood to the protein-free perfusion medium but highly reduced by newborn calf serum (NCS). The SDS-PAGE (sodium dodecyl sulfate-polyacrylamide gel electrophoresis) analysis of proteins adsorbed on the nanoparticles incubated in NCS reveals major coating by albumin and IgG. The addition of bovine IgG to the perfusion fluid reduces the rate of MSM uptake in the same extent that NCS, whereas fetal calf serum that contains only traces of IgG weakly alters the MSM clearance. Finally, complemented and decomplemented NCS exhibit the same influence on the MSM hepatic extraction. It is concluded that although lectins are largely involved in the uptake of MSM administered in the absence of proteins, opsonins receptors are implicated when the perfusion medium contains relevant blood components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705258
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparisons of spontaneous pain and tenderness in patients with primary fibromyalgia (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 168-173 
    Details
    ISSN: 1434-9949
    Keywords: Fibromyalgia ; Pain Measurement ; Visual Analog Scale ; Pain Score ; Dolorimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pain was assessed in 47 patients with fibromyalgia in the University Rheumatology Clinic in Basle with the aid of three different techniques. First, a simple visual analog scale was used, later a body diagram on which patients could indicate pain separately in different regions of the body (pain score) and, finally, dolorimetric measurements at 56 typical PFS tender points. After four weeks of therapy, pain was again scored by patients using these techniques. The changes in assessment were compared with the aid of Spearman correlation. Data recorded with the aid of the body diagram correlated better with dolorimetric findings than did the results obtained from a simple visual analog scale. The severity of the disease can be more objectively assessed using these three techniques than it can using only the visual analog scale. In particular, the pain score and dolorimetry make possible a clear assessment of the value of therapeutic regimens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207658
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cold-induced vasospasm in patients with fibromyalgia and chronic low back pain in comparison to healthy subjects (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 442-445 
    Details
    ISSN: 1434-9949
    Keywords: Capillary Videomicroscopy ; Vasospasm ; Cold Provocation Test ; Fibromyalgia ; Low Back Pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using capillary videomicroscopy of the nail fold, the frequency of cold-induced vasospasm and capillary hemodynamic parameters were studied after application of cold in 50 patients with primary fibromyalgia, 50 patients with chronic low back pain, and 50 healthy controls. Cold-induced vasospasm was detected in 38% of the patients with fibromyalgia. In this group it was significantly more frequent than in the patients with chronic low back pain (20%, p〈0.05) and healthy subjects (8%, p〈0.001). In the fibromyalgia group, the magnitude of vasospasm as measured by the capillary blood flow deceleration after cold application correlated negatively with the pain intensity as measured by pain score (r=−0.3839, p〈0.01). No differences in clinical appearance were found between patients with and without cold-induced vasospasm in both the fibromyalgia and low back pain group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242940
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    In vitro relaxometric characterization of superparamagnetic contrast agents (1993)
    Springer
    Magnetic resonance materials in physics, biology and medicine 1 (1993), S. 83-88 
    Details
    ISSN: 1352-8661
    Keywords: MRI contrast agents ; superparamagnetic particles ; relaxometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics
    Notes: Abstract The relaxation behaviour of solvent protons of aqueous dispersions of single crystals, and of small agglomerates of superparamagnetic materials, has been measured at 0.47 T and 37 °C, and compared with that of larger systems like magnetic spheres or large agglomerates of magnetic grains. The longitudinal recovery of the nuclear magnetization, as well as its transverse decay, allow for mono-exponential fits only for dispersions of small particles, sized up to a few tens of nanometers. In this case the transverse relaxation rateR 2 is independent of the echo time, and has a linear relationship to the iron concentration. For larger particles or agglomerates of a diameter lying within the micrometer range, the transverse evolution obtained with a Carr-Purcell-Meiboom-Gill (CPMG) sequence is characterized by a marked influence of the inter-pulse delay (TE), and has to be described by a multiexponential regime including a very fast initial decay. The initial fall in magnetization is one of the most prominent features of the large-size systems and, together with the parameters describing the subsequent multiexponential regime, is an important factor in the description of their effect. This parameter may be valuable in the comparison of such agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01760404
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    Paper (German National Licenses)
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