ISSN:
1432-0533
Keywords:
Germanium intoxication
;
Mitochondrial myopathy
;
Ragged-red fiber
;
Autophagic vacuole
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The long-term administration of germanium dioxide (GeO2) to rats produced Ge myopathy characterized by the formation of ragged-red fibers. The earliest pathological changes in experimental Ge myopathy were a decrease in cytochrome c oxidase activity and accumulation of high electron-dense materials in mitochondria. These findings suggest that a mitochondrial dysfunction may be most important in the genesis of experimental Ge myopathy, which could be a useful animal model for the investigation of and therapeutic trials for human mitochondrial myopathies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310923
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