ISSN:
1433-2965
Keywords:
Collagen
;
Gestogen
;
Menopause
;
Oestrogen
;
Osteoporosis
;
Procolgen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We investigated the effect of the menopause and postmenopausal hormone replacement therapy on the serum concentration of carboxyterminal propeptide of type I procollagen (PICP), which is a biochemical marker of type I collagen synthesis. A group of 124 healthy postmenopausal women, aged 45–53 years, had about 20% higher serum PICP than did a group of 40 healthy premenopausal women aged 35–52 years (114±35 µg/1 vs. 95±26 µg/l (mean ± SD);p=0.002). The 124 postmenopausal women were also participating in a double-masked longitudinal study with two placebo groups and four different hormone replacement therapy groups. The four hormone regimens resulted in similar responses in serum PICP. Compared with placebo, 1 year of treatment with any of the four hormone replacement therapies significantly decreased serum PICP to premenopausal levels. We conclude that the formation of type I collagen is increased shortly after the menopause and that hormone replacement therapy reverses this increase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01623177
Permalink
