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  • 1
    Digitale Medien
    Digitale Medien
    Immunofluorescent localization of tenascin during the morphogenesis of the outflow tract of the chick embryo heart (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 149-155 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Heart morphogenesis ; Truncus Arteriosus ; Extracellular matrix ; Tenascin ; Collagen type I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The cono-truncus constitutes a complex segment of the developing heart that gives rise to the outflow tract of the ventricles and root of the pulmonary and aortic arteries. Numerous studies have revealed that the extracellular matrix plays a relevant role in most morphogenetic processes modulating cell behaviour. By means of immunofluorescence, we studied the distribution and possible involvement of tenascin during morphogenesis of the conus and truncus in chick embryo hearts between days 4.5–10 of incubation. Tenascin is an extracellular matrix glycoprotein with a significant role in morphogenesis and cell and tissue differentiation. Our results reveal a specific distribution of tenascin in the areas of the cono-truncus undergoing significant structural changes during morphogenesis of this cardiac segment, appearing mainly in the mesenchymal layer subjacent to the myocardial layer, the cono-truncal ridges and the aorto-pulmonary septum. The distribution of tenascin was compared and contrasted with that of collagen type I, which constitutes a further component of the extracellular matrix common to most developing connective tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00198954
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Histogenesis of the semilunar valves: an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves (1990)
    Springer
    Cell & tissue research 259 (1990), S. 299-304 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Semilunar valves ; Extracellular matrix ; Tenascin ; Type-I collagen ; Heart morphogenesis ; Domestic fowl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The development of the semilunar valves takes place in association with septation of the outflow tract in the embryonic heart. Although numerous studies have focused on this process, the causal mechanisms of valvular development remain obscure. This paper reports an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves. Tenascin is a glycoprotein that is present on some embryonic extracellular matrices. It plays several significant roles in tissue differentiation, cell growth, and tissue interactions; it is also important for the formation of specific zones of connective tissue that fulfill mechanical functions. Our results show that tenascin is present during valvular morphogenesis and histogenesis, and that its distribution is associated with zones specialized in bearing mechanical loads.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00318452
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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