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  • 1990-1994  (2)
  • IL-1β  (1)
  • Physarum polycephalum
  • 1
    Electronic Resource
    Electronic Resource
    Modulation of C2 and C3 gene expression of human peripheral blood monocytes by interleukin 1β, interferon γ, tumor necrosis factor α and lipopolysaccharide (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 1148-1150 
    Details
    ISSN: 1420-9071
    Keywords: IL-1β ; IFNγ ; LPS ; C2 ; C3
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of interleukin 1β (IL-1β), interferon γ (IFN-γ), tumor necrosis factor α (TNFα) and lipopolysaccharide (LPS) on the expression of the C2 and C3 genes in human adherent monocytes was studied. Stimulation of monocytes with IFN-γ increased both C2 and C3 mRNA. IL-1β also increased C2 mRNA level, whereas C3 gene expression was not enhanced. TNFα failed to increase either C2 or C3 mRNA. LPS increased C2 mRNA, but suppressed C3 gene expression. These results suggest that C2 and C3 production by monocytes is regulated by IL-1β and IFN-β in the local tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01948011
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Development of spatio-temporal pattern of Ca2+ on the chemotactic behaviour ofPhysarum plasmodium (1992)
    Springer
    Protoplasma 166 (1992), S. 55-60 
    Details
    ISSN: 1615-6102
    Keywords: Physarum polycephalum ; Spatio-temporal pattern of Ca2+ ; concentration ; Information processing ; Intracellular Ca2+ ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The development of a spatio-temporal pattern of Ca2+ concentration by a plasmodium ofPhysarum polycephalum during chemotaxis was studied using fura-2. Whenever the cell displayed coordinated migration in one direction as a whole body, a spatiotemporal pattern was established with a characteristic feature along the longitudinal axis. Calcium concentration oscillated with a period of a few minutes within the cell; the mean concentration at the front was higher than that at the rear. When the cell was given an attractant only at the rear end, the mean concentration rose at the site of application with an immediate increase in the frequency of oscillation. First, the change of the frequency is propagated toward the other end and then the mean level of the Ca2+ concentration at the non-stimulated site decreases. As a result, the Ca2+ gradient is reversed along the cell, which then begins to migrate in a coordinated manner in the reverse direction. This study showed that the spatiotemporal pattern of Ca2+ concentration is closely related to information processing for coordinated migration in chemotaxis. The role of the pattern in that process is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01320143
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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