Electronic Resource
Springer
European journal of pediatrics
153 (1994), S. 241-244
ISSN:
1432-1076
Keywords:
Key words: Testotoxicosis – Precocious puberty – Suppressed gonadotrophins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. We report two cases of `familial testotoxicosis' in a family of Southern Chinese descent. The proband, an 8-year 4-month-old boy and his 35-year-old father both presented with early sexual development. In both cases the testicular volume was only 6 ml despite fully developed secondary sexual characteristics. Both patients had adult testosterone concentrations but a suppressed gonadotrophin response to gonadotrophin-releasing hormone. The suppressed gonadotrophin response to gonadotrophin-releasing hormone in the father suggests that autonomous gonadal production of sex steroid by the testes can persist well into adult life in some patients with familial testotoxicosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954510
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