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Early diagnosis of optic glioma in children with neurofibromatosis type 1 (1994)

Rossi, L. N. ; Pastorino, G. ; Scotti, G. ; [et al.]

Springer

Child's nervous system 10 (1994), S. 426-429

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ISSN: 1433-0350

Keywords: Neurofibromatosis ; Magnetic resonance imaging ; Optic glioma ; Visual function ; Visual evoked potentials

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Twenty-five asymptomatic patients with neurofibromatosis type 1 (NF 1), aged 6–21 years, underwent the following examinations: intracranial magnetic resonance testing (MRI), visual acuity testing, ophthalmoscopy, and visual field and pattern reversal visual evoked potentials (VEPs). MRI showed enlargement of one or both optic nerves in six children, with bilateral involvement in three. VEPs were normal in all these patients; two of them had abnormalities on other visual examinations, although there were no subjective visual disturbances. These results show that VEPs cannot be considered as a screening test for optic pathway lesions in children with NF 1, as previously stated, and that other types of visual function examination may be more sensitive. These data may contribute to the establishment of more precise guidelines for the evaluation and treatment of children with NF 1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00303606

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Relation between hyaluronan and sulphated glycosaminoglycan synthesis and degradation in cultured embryonic fibroblasts. Effect of concanavalin a and ammonium chloride administration (1991)

Carinci, P. ; Locci, P. ; Evangelisti, R. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Cell Biochemistry and Function 9 (1991), S. 255-262

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ISSN: 0263-6484

Keywords: Hyaluronan ; glycosaminoglycans ; GAG synthesis ; GAG degradation ; chick embryo ; fibroblasts ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: In order to evaluate the relationship between glycosaminoglycan (GAG) synthesis and degradation, the effect of NH4Cl, which inhibits lysosomal degradation, on GAG production was analysed in vitro in concanavalin A (Con A) stimulated fibroblasts from 7 and 14-day-old chick embryos. 35SO4 incorporation into total proteoglycan (PG), 3H incorporation into individual GAG classes, β-N-acetyl-D-glucosaminidase and β-D-glucuronidase activity were determined. The results indicate a correlation between Con A and NH4Cl effects: NH4Cl induced a reduction principally in the GAG classes most stimulated by Con A. Thus HA and DS are much more stimulated by Con A and inhibited by NH4Cl than are CS and HS.

Additional Material: 2 Ill.