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  • 1990-1994  (2)
  • Multifidus  (1)
  • Propranolol  (1)
  • 1
    ISSN: 1432-1041
    Keywords: Atenolol ; Propranolol ; Pindolol ; transthoracic electrical bioimpedance ; cardiac output ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have evaluated Sramek's method of impedance cardiography as a non-invasive way of detecting the cardiovascular effects of drugs. We made cardiovascular measurements using the method during passive tilting and exercise 2 h after the oral administration of atenolol (50 and 100 mg), propranolol (40 and 80 mg), pindolol (5 and 10 mg), and placebo in seven separate studies involving eight healthy male volunteers. Equivalent doses of the pure antagonists atenolol (β1) and propranolol (β1, β2) produced similar reductions in heart rate, systolic blood pressure, and cardiac index, and increases in stroke volume and total peripheral resistance, particularly during exercise. In contrast the partial agonist pindolol produced increases in heart rate and cardiac index, and reductions in peripheral resistance at rest. During passive tilting and exercise pindolol reduced heart rate, but cardiac output and total peripheral resistance were unchanged except at the highest levels of exercise. The similar cardiovascular effects of atenolol and propranolol, but differing effects of pindolol, are consistent with reports using other methods of measurement. This suggests that impedance cardiography may have a place in the non-invasive assessment of the cardiovascular effects of drugs.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European spine journal 1 (1992), S. 38-42 
    ISSN: 1432-0932
    Keywords: Muscles paravertébraux ; Muscle multifide ; Anthropométrie ; Lombalgie ; Paraspinal muscles ; Multifidus ; Anthropometry ; Low back pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This study of 52 patients (27 men) with recent (18 months) or chronic (〉18 months) low back and unilateral radicular pain symptoms was undertaken to investigate whether wasting of the paraspinal muscle components is generalised or selective. During the patients' routine computed tomographic lumbar spinal scans a standardised transaxial view was obtained along the upper end-plate of the L4 vertebra, and the cross-sectional areas of the paraspinal muscles and their components, multifidus and erector spinae, estimated. Irrespective of whether the symptoms were recent or chronic, multifidus dimensions were significantly greater on the side ipsilateral to the radicular pain symptoms. The results indicate selective changes of multifidus in these patients and possibly reflect an adaptive response by this muscle, such as to an increased role in stabilising the lumbar spine in the face of overall paraspinal muscle atrophy.
    Notes: Résumé Cette étude a été réalisée chez cinquante deux patients (27 hommes, 25 femmes), présentant une lombalgie soit récente (depuis moins de 18 mois), soit chronique (depuis plus de 18 mois) associée à une radiculalgie unilatérale. Le but de la recherche était de déterminer si l'atrophie des muscles paravertébraux était globale ou élective. Lors de l'examen scannographique de routine pratiqué chez ces patients, une coupe transversale a été pratiquée le long du plateau supérieur de la 4e vertèbre lombaire, permettant d'évaluer l'étendue de la surface occupée par ces muscles paravertébraux et leurs composants, plus particulièrement le muscle multifide et le muscle érecteur du rachis. Les résultats indiquent des modifications électives du muscle multifide chez les patients porteurs de lombalgies, et réflètent vraisemblablement une réponse adaptative de ce muscle qui semble jouer un rôle accru dans la stabilisation du rachis lombaire face à l'atrophie globale des muscles paravertébraux.
    Type of Medium: Electronic Resource
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