ZIB

Hits per page

hit 1 - 1 | 1 hit

Sorting

Electronic Resource

New antitumoral cyclopeptides (1994)

Bernardi, E. ; Fauchère, J-L. ; Atassi, G. ; [et al.]

Springer

Amino acids 6 (1994), S. 315-318

add to mindlist on the mindlist

Details

ISSN: 1438-2199

Keywords: Amino acids ; Peptides ; Cyclopeptides ; Chlamydocin ; HC toxin ; Alkylating agent ; Antitumoral agent

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Chlamydocin is a powerfulin vitro antitumoral agent, quickly inactivatedin vivo. A series of cyclic tetrapeptides related to chlamydocin or HC toxin and bearing a bioactive alkylating group on anε-amino-lysyl function have been examined for their antitumoral activity on L1210 and P388 murine leukemia cell lines. One analog was found to be potent at inhibiting L1210 cell proliferation and had a higher therapeutic index than the reference compound bis-β-chloroethylnitrosourea on thein vivo P388-induced leukemia model.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00813752

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

hit 1 - 1 | 1 hit