ISSN:
1573-904X
Keywords:
pentachlorophenol
;
tetrachlorohydroquinone
;
toxicokinetics
;
metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The toxicokinetics of pentachlorophenol (PCP) were studied in B6C3F1 mice, a strain in which PCP was previously found to be carcinogenic. In a crossover design, doses of 15 mg/kg were given intravenously (bolus) and orally (gastric intubation) to six animals. Concentrations of PCP in blood, urine, and feces were measured by capillary gas chromatography with electron-capture detection. After intravenous administration, the values of clearance and volume of distribution were 0.057 ± 0.007 L/hr/kg and 0.43 ± 0.06 L/kg, respectively. These two parameters exhibited low intermouse variability (coefficients of variation 〈14%). The elimination half-life was 5.2 ± 0.6 hr. After oral administration, the PCP peak plasma concentration (28 ± 7 µg/ml) occurred at 1.5 ± 0.5 hr and absorption was complete (bioavailability = 1.06 ± 0.09). The elimination half-life was 5.8 ± 0.6 hr. Only 8% of the PCP dose was excreted unchanged by the kidney. PCP was primarily recovered in urine as conjugates. A portion of the dose was recovered in urine as the mutagen, tetrachlorohydroquinone (5%) (TCHQ), and its conjugates (15%). For both PCP and TCHQ, sulfates accounted for 90% or more of the total conjugates (glucuronides and sulfates).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015810629245
Permalink
