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Digitale Medien

Immunological comparison between prostate-specific antigen and γ-seminoprotein (1991)

Deguchi, T. ; Kuriyama, M. ; Shinoda, I. ; [weitere]

Springer

Urological research 19 (1991), S. 25-30

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ISSN: 1434-0879

Schlagwort(e): Prostate cancer ; Tumor marker ; Prostate-specific antigen ; γ-Seminoprotein

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Prostate-specific antigen (PA) and γ-seminoprotein (γ-Sm) were compared by immunocytochemical, immunodiffusion and immunoblotting methods using rabbit anti-PA antibody and rabbit anti-γ-Sm antibody. Enzyme immunoassys (EIAs) were developed for measurements of PA and γ-Sm to determine a correlation between serum PA and γ-Sm levels in patients with prostate cancer. The patterns of localization and distribution of PA and γ-Sm were identical in prostate tissue sections, including benign and cancerous human prostacs. The immunodiffusion study showed that the antigens with which anti-PA antibody and anti-γ-Sm antibody reacted in seminal plasma and prostate tissue homogenates were identical to each other. In the immunoblotting study, anti-PA antibody and anti-γ-Sm antibody recognized a single antigen corresponding to a molecular weight of approximately 33,000 both in seminal plasma and prostate tissue homogenates. The EIAs developed in this study were sensitive, specific, and reproducible, and the correlation between serum PA and γ-Sm values determined by these EIAs was highly significant (r=0.99, P(0.001). These results indicated that PA and γ-Sm were immunologically identical and that serum PA and γ-Sm determined by immunoassays using anti-PA antibody and anti-γ-Sm antibody should be evaluated as identical tumor markers for serodiagnosis of prostate cancer.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00294017

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Digitale Medien

Kinetics and mechanism of emulsion polymerization initiated by oil-soluble initiators. II. Kinetic behavior of styrene emulsion polymerization initiated by 2,2′-azoisobutyronitrile (1991)

Nomura, M. ; Yamada, A. ; Fujita, S. ; [weitere]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part A: Polymer Chemistry 29 (1991), S. 987-994

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ISSN: 0887-624X

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: In order to clarify the general kinetic behavior of emulsion polymerization initiated by oilsoluble initiators, the emulsion polymerization of styrene initiated by 2,2′-azoisobutyronitrile was as a typical example, investigated thoroughly. The variations of the polymerization rate and the number of polymer particles produced with changes in emulsifier (sodium lauryl sulfate), initiator, and monomer concentrations initially charged and the reaction temperature were determined. It is shown from these experimental results that the kinetic behavior of this emulsion polymerization system is quite similar to that of styrene emulsion polymerization initiated by the water-soluble initiator, potassium persulfate despite the difference in the principal loci of radical production in both systems.

Zusätzliches Material: 14 Ill.