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  • 1
    Electronic Resource
    Electronic Resource
    RU 41 656 does not reverse the scopolamine-induced cognitive deficit in healthy volunteers (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 225-231 
    Details
    ISSN: 1432-1041
    Keywords: RU 41 656 ; Scopolamine ; pharmacodynamics ; psychomotor performance ; memory ; drug interaction ; dementia model ; dopamine (D2) agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The potential antagonism of a single oral dose of RU 41 656 10 mg on the memory and attention disturbances induced by scopolamine 0.6 mg s.c. have been investigated in a 3 period, placebo controlled, double blind, cross over study in 12 healthy, young volunteers. The effects of the compounds were evaluated by objective tests (Buschke selective reminding test, CFF, simple reaction time, tapping, arithmetical calculation) and subjective measurements (visual analogue scale, side effects questionnaire). Measurements were taken before treatment and 2, 4 and 7 h after RU 41 656. Scopolamine caused anterograde amnesia and sedative effects as which were not counteracted by RU 41 656.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315434
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Study of the potential reversal of triazolam memory and cognitive deficits by RU 41 656 in healthy subjects (1991)
    Springer
    Psychopharmacology 104 (1991), S. 75-80 
    Details
    ISSN: 1432-2072
    Keywords: Pharmacodynamics ; Psychomotor performance ; Drug interaction ; Triazolam ; Dementia model ; RU 41 656
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The potential antagonism of a single oral dose of RU 41 656 (10 mg) on the memory and attention disturbances induced by oral administration of triazolam (0.25 mg) have been investigated in a 3-period, placebo controlled, double blind, cross-over study involving 12 healthy young volunteers. The effects of the compounds were evaluated by objective tests (Buschke selective reminding test, CFF, simple reaction time, tapping, arithmetical calculation) and subjective measurements (visual analogue scale, side effects questionnaire). Measurements were taken before treatment and 2, 4 and 7 h after RU 41 656 intake. Triazolam caused anterograde amnesia as already described with other benzodiazepine with few sedative effects at this dosage. Under the experimental conditions of the trial, RU 41 656 failed to counteract the memory deficits induced by triazolam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244557
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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