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  • 1990-1994  (3)
  • Stereology  (3)
  • 1
    Electronic Resource
    Electronic Resource
    The volume of Purkinje cells decreases in the cerebellum of acrylamide – intoxicated rats, but no cells are lost (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 307-312 
    Details
    ISSN: 1432-0533
    Keywords: Key words Acrylamide ; Cerebellum ; Neuronal volume ; Neuronal number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acrylamide intoxication on the numbers of granule and Purkinje cells and the volume of Purkinje cell perikarya have been evaluated with stereological methods. The analysis was carried out in the cerebella of rats that had received a dose of 33.3 mg/kg acrylamide, twice a week, for 7.5 weeks. The total numbers of cerebellar granule and Purkinje cells were estimated using the optical fractionator and the mean volume of the Purkinje cell perikarya was estimated with the vertical rotator technique. The volumes of the molecular layer, the granular cell layer and the white matter were estimated using the Cavalieri principle. The mean weight of the cerebellum of the intoxicated rats was 7   % lower than that of the controls rats (2P = 0.001). The numbers of the Purkinje cells and granule cells were the same in both groups, but the mean volume of the perikarya of the Purkinje cells in the intoxicated rats was 10.5   % less than that of the control group (2P = 0.004). The volume of the granular cell layer was reduced by 15   % (2P = 0.006) but there were no differences in the volumes of the molecular layer and the white matter in the intoxicated and control animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310374
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The volume of Purkinje cells decreases in the cerebellum of acrylamide — intoxicated rats, but no cells are lost (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 307-312 
    Details
    ISSN: 1432-0533
    Keywords: Acrylamide ; Cerebellum ; Neuronal volume ; Neuronal number ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of acrylamide intoxication on the numbers of granule and Purkinje cells and the volume of Purkinje cell perikarya have been evaluated with stereological methods. The analysis was carried out in the cerebella of rats that had received a dose of 33.3 mg/kg acrylamide, twice a week, for 7.5 weeks. The total numbers of cerebellar granule and Purkinje cells were estimated using the optical fractionator and the mean volume of the Purkinje cell perikarya was estimated with the vertical rotator technique. The volumes of the molecular layer, the granular cell layer and the white matter were estimated using the Cavalierí principle. The mean weight of the cerebellum of the intoxicated rats was 7% lower than that of the controls rats (2P=0.001). The numbers of the Purkinje cells and granule cells were the same in both groups, but the mean volume of the perikarya of the Purkinje cells in the intoxicated rats was 10.5% less than that of the control group (2P=0.004). The volume of the granular cell layer was reduced by 15% (2P=0.006) but there were no differences in the volumes of the molecular layer and the white matter in the intoxicated and control animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310374
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of chronic lithium treatment with or without haloperidol on number and sizes of neurons in rat neocortex (1994)
    Springer
    Psychopharmacology 115 (1994), S. 371-374 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Haloperidol ; Neocortex ; Rats ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study used stereological methods to determine whether long-term administration of lithium, with or without haloperidol, affects the number and average volume of neocortical neurons. Twenty-five rats were divided into three groups and given no treatment, lithium, or lithium combined with haloperidol. Serum lithium levels ranged from 0.5 to 0.8 mmol/l. Haloperidol was injected intraperitoneally at a daily dose of 1 mg/kg. After 30 weeks of treatment, the animals were killed and the brains were prepared. Neocortical volume, density of neurons, total number of neurons and mean volume of neurons were estimated. As no differences were found between the groups, the present study provides no evidence for quantitative morphological changes in the cerebral cortex due to long-term ‘therapeutic’ levels of lithium, with or without haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245079
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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