ISSN:
1432-1041
Keywords:
domperidone
;
pergolide
;
dopaminergic agonists
;
intraocular pressure
;
non-contact tonometer
;
drug interaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary 1 The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 μg pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2 Compared with domperidone followed after 1 h by placebo, placebo followed after 1 h by pergolide had an ocular hypotensive effect in both eyes. Domperidone followed after 1 h by pergolide had no effect on intraocular pressure in both eyes. 2 The results of this study showed that domperidone inhibited the ocular hypotensive action of pergolide, suggesting that pergolide reduces introcular pressure by the stimulation of the peripheral dopamine 2-receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02336684
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