ISSN:
1435-1463
Keywords:
Melatonin receptors
;
seasonal variation
;
photoperiod
;
pars tuberalis
;
reproductive state
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Using quantitative autoradiography, we have studied the relationship between melatonin receptor density in the pars tuberalis (PT) and photoperiodic changes in sexual activity in a photoperiodic (Syrian hamster), and a non photoperiodic (rat) rodent. Syrian hamsters exposed to short photoperiod (SP) for 13 weeks or kept in long photoperiod (LP) with daily melatonin injections for 8 weeks, had both gonadal regression and a significant decrease in 2-125I-melatonin binding site density in the PT when compared to controls. In contrast, when the animals were sexually active, photorefractory Syrian hamsters exposed to SP for 27 weeks, or rats kept for 13 weeks in SP, the PT melatonin receptor density was similar to that of control animals kept in LP. These results show clearly that a correlation exists between gonadal status and density of melatonin receptors in the PT and suggest that the PT could be the site where melatonin mediates its effects on seasonal function.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01294786
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