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  • 1
    Electronic Resource
    Electronic Resource
    Relationship between bone fluoride content and histological evidence of calcification defects in osteoporotic women treated long term with sodium fluoride (1993)
    Springer
    Osteoporosis international 3 (1993), S. 204-208 
    Details
    ISSN: 1433-2965
    Keywords: Bone ; Bone fluoride content ; Calcification defects ; Osteoporosis ; Sodium fluoride treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fluoride treatment is used to increase bone formation and cancellous bone mass in patients suffering from postmenopausal osteoporosis with vertebral fractures. Patients submitted to similar therapeutic protocols have shown various histological responses to the treatment, some developing calcification defects and others not. In fact, the bone histological response to fluoride salts depends on the cumulative uptake of fluoride by bone. To clarify the relationship between the presence of calcification defects (identified by the presence of mottled bone and linear formation defects) and the bone fluoride content, a retrospective study was performed on 29 women with type 1 osteoporosis and treated for several months (11–24) with sodium fluoride (50 mg/day), calcium and vitamin D. Bone fluoride content always significantly increased after treatment, but it was significantly higher in patients showing calcification defects than in those having no defects. These differences between the two groups of patients were not due to differences in clinical details (no significant differences concerning age, duration of treatment, total amount of fluoride ingested, renal function) or in their bone remodelling activity. Thus, it may be hypothesized that the high bone fluoride uptake is due to different individual responses from one patient to another concerning the bioavailability of the same dose of fluoride. This is difficult to predict, except by testing the individual bioavailability of the compound to be used in each patient before starting long-term treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623677
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  • 2
    Electronic Resource
    Electronic Resource
    Fluoride-induced bone changes in lambs during and after exposure to sodium fluoride (1991)
    Springer
    Osteoporosis international 2 (1991), S. 26-33 
    Details
    ISSN: 1433-2965
    Keywords: Bone fluoride content ; Bone remodeling ; Fluoride ; Histomorphometry ; Lambs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evolution of bone changes induced by fluoride after the end of exposure was investigated in lambs. Sodium fluoride (NaF) was given orally at a dose of 3.5 mg/kg per day to 14 animals for 120 days. A group of 7 control and 7 treated lambs was slaughtered at the end of NaF administration (T120) and another group 120 days after the end of NaF exposure (T240). At T120, the bone fluoride content (BFC) was very significantly increased in treated animals. The histomorphometric analysis confirmed that fluoride induces an increase in bone formation (the osteoid perimeter and area were 3-fold and 4.5-fold higher respectively in treated than in control animals). The number of osteoblasts was significantly augmented. Serum osteocalcin level was twice as high in treated animals compared with controls. The bone formation rate at the tissue level (BFR) doubled after treatment, but the apposition rate (Aj.AR) was half that in the control group. The mineralization lag time (Mlt) was 120 days in treated animals compared with 42 days in controls. At T240, BFC had decreased by 50% compared with the level at T120, but it was still significantly higher than in controls. The osteoid and osteoblastic parameters were 2 and 1.3 times higher than in control animals. BFR remained significantly increased in treated animals, but Aj.AR and Mlt were similar in control and treated animals. In conclusion, after 4 months of NaF exposure fluoride induced an increase in osteoblast natality and bone formation at the tissue level, associated with a toxic effect at the individual cell level. Four months after the end of NaF exposure, positive effects on bone formation were still present but the evidence of cellular toxicity had disappeared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01627075
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  • 3
    Electronic Resource
    Electronic Resource
    Fluoride salts for vertebral osteoporosis: The benefit-to-risk ratio depends on the cumulative dose reaching bone (1993)
    Springer
    Osteoporosis international 3 (1993), S. 211-214 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion In conclusion, until recently the message concerning the benefit-to-risk ratio of fluoride therapy in established vertebral osteoporosis has been rather confusing because ‘fluoride’ has been considered globally, without taking into account the fact that quite different therapeutic strategies have used different fluoride salts, doses, durations of treatments and preparations with very different bioavailabilities of fluoride ion. Low daily doses (50 mg) of sodium fluoride given in enteric-coated tablets for 2 years correspond to a safe therapeutic window. They provide a valid benefit-to-risk ratio when administered concomitantly with calcium supplements and when the classical contraindications of renal failure and osteomalacia are taken into account.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01621910
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  • 4
    Electronic Resource
    Electronic Resource
    Immunocytological localization of 1,25-dihydroxyvitamin D3-like molecules and their receptors in a calcium-transporting epithelium of a crustacean (1991)
    Springer
    Cell & tissue research 263 (1991), S. 345-351 
    Details
    ISSN: 1432-0878
    Keywords: Vitamin D-1,25(OH)2D3-like immunoreactivity ; 1,25(OH)2D3 receptor-like immunoreactivity ; Immunocytochemistry ; Calcium ions ; Orchestia cavimana (Crustacea)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary For the first time, immunoreactivity to 1,25(OH)2D3-like molecules and their receptors has been investigated in a calcium transporting epithelium of a crustacean, Orchestia, using vertebrate antisera on ultrathin cryosections of posterior caeca previously fixed in glutaraldehyde, then postfixed in osmium tetroxide. Both immunoreactivities were located mainly in the nuclei of epithelial cells. Quantitative differences in 1,25(OH)2D3-like immunoreactivity were noticed from one stage of the molt cycle to another. These results, together with other data, contribute to evidence that immunoreactive 1,25(OH)2D3-like molecules may be involved in the regulatory processes of calcium metabolism in this terrestrial crustacean and suggest an involvement of these substances in the regulation of calcium movements in the posterior caeca.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318776
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for a direct effect of growth hormone on osteoblasts (1993)
    Springer
    Cell & tissue research 273 (1993), S. 279-286 
    Details
    ISSN: 1432-0878
    Keywords: Osteoblasts ; Growth hormone ; Growth hormone-receptor ; Alkaline phosphatase ; Immunocytology ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In order to determine whether growth hormone (GH) exerts a direct effect on osteoblasts, in vitro and in vivo immunocytological studies were carried out on newborn rat calvaria and a clonal osteoblast-like cell line (MC3T3-E1) isolated from newborn mouse calvaria. After exposure to human growth hormone (hGH) or 1,25 dihydroxyvitamin D3 (1,25(OH)2D3), a significant increase in alkaline phosphatase activity was observed in MC3T3-E1 cells. Simultaneous exposure of MC3T3-E1 cells to hGH and 10 nM 1,25(OH)2D3 showed a synergistic effect of the two hormones on this activity. The optimal dose of hGH was 0.1 nM. An immunocytological procedure was performed on ultrathin frozen sections from 7-day-old rat calvaria and MC3T3-E1 cells cultured with hGH. GH-like immunoreactivity was observed in both cases. In calvaria, endogenous GH-like immunoreactivity was localized at the same ultrastructural level (plasma membrane, cytoplasmic and nuclear matrices) as exogenous GH-like immunoreactivity in MC3T3-E1 cells. Following the initial step of binding to the plasma membrane, GH may be internalized in the cytoplasmic matrix and nucleus. In situ hybridization revealed the presence of mRNA coding for GH receptor in calvaria cells. The density of these receptors seemed to be lower in osteoblasts than in hepatocytes. In MC3T3-E1 cells, hGH induced a dose-dependent secretion of insulin-like growth factor 1. In conclusion, these results indicate that GH may act directly on osteoblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312829
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of ossein-hydroxyapatite compound on ewe bone remodeling: Biochemical and histomorphometric study (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 269-273 
    Details
    ISSN: 1434-9949
    Keywords: Ossein-Hydroxyapatite Compound ; Bone Remodeling ; Biochemistry ; Histomorphometry ; Ewe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ossein-hydroxyapatite compound (OHC) is a protein-mineral complex derived from bovine bone. Its effects on bone remodeling were studied in old ewes which have seasonal variations in bone remodeling. Seven animals received 200 mg OHC/kg b.w./day for 90 days from July to September. The control group consisted of 7 untreated animals followed for the same period of time. OHC was administered through a fistula into the fourth stomach. A significant decrease of bone histomorphometric parameter values was noted in controls at the end of the experiment, due to seasonal variations: the cancellous eroded perimeter decreased by 45%, the osteoblastic perimeter by 60% and the bone formation rate at the cell level by 20%. In contrast, in the treated-group, these parameters tended to increase or did not change. In conclusion, counteracting the significant seasonal reduction of bone remodeling in ewes, OHC seems able to stimulate directly or indirectly bone metabolism, especially when osteoblast activity is reduced and may partly prevent the seasonal reduction of bone turnover.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208688
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison between radial bone mineral density measured by single photon absorptiometry and histomorphometric bone mass parameters measured on iliac crest biopsies (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 367-373 
    Details
    ISSN: 1434-9949
    Keywords: Bone Mineral Density ; Single Photon Absorptiometry ; Iliac Crest Biopsy ; Bone Mass Histomorphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone mineral density (BMD) measured by single photon absorptiometry (SPA) with a Moolsgard 1100® device on the distal and proximal part of the radius was compared with histomorphometric parameters measured on iliac crest biopsies in 37 patients suffering from various bone disorders. In the whole population, a good correlation was observed between the cancellous bone volume (Cn-BV/TV) measured on iliac crest biopsies and BMD from both the proximal part of the radius (r=0.76, p 〈 0.001) and the distal part of the radius (r=0.73, p 〈 0.001). Significant, although weaker correlations, were also found between the cortical width and the BMD from the distal part (r=0.37, p 〈 0.001) and the proximal part (r=0.44, p 〈 0.001) of the radius. In the 14 untreated osteoporotic patients, only a significant Spearman correlation was observed between the iliac Cn-BV/TV and the proximal radial BMD (r′=0.69, p 〈 0.05). It is thus not clear, whether radial proximal BMD correctly indicates cortical bone density in osteoporotic patients or not. The large internal variability of each of the two investigated methods and the small group of osteoporotic patients might explain the lack of correlation between the two methods in this group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114398
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  • 8
    Electronic Resource
    Electronic Resource
    Predatory mirids of the green apple aphidAphis pomi, the two-spotted spider miteTetranychus urticae and the European red mitePanonychus ULMI in apple orchards in Québec (1992)
    Springer
    BioControl 37 (1992), S. 283-292 
    Details
    ISSN: 1573-8248
    Keywords: Predatory mirids ; Miridae ; Aphis pomi ; Tetranychus urticae ; Panonychus ulmi ; Miridae ; Aphis pomi ; Tetranychus urticae ; Panonychus ulmi ; prédateur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Le niveau de prédation de huit espèces de mirides prédateurs (Hemiptera: Miridae) présents en verger de pommiers au Québec a été établi pour le puceron vert du pommier, le tétranyque à deux points et le tétranyque rouge du pommier. Le taux de consommation journalier a varié de 1–2 pucerons vert du pommier pourHyaliodes vitripennis Say etCampylomma verbasci Meyer à 7–9 pucerons pourDeraeocoris fasciolus Knight etLepidopsallus minisculus Knight.H. vitripennis a consommé significativement plus de tétranyques que les autres espèces de mirides avec 26 et 18 tétranyques à deux points et tétranyques rouge du pommier respectivement. L'utilisation combinée deH. vitripennis etL. minisculus est suggérée pour la lutte biologique contre les tétranyques du pommier.
    Notes: Abstract The incidence of predation of eight species of predacious mirids (Hemiptera: Miridae) present in an apple orchard of Québec on the green apple aphid, two-spotted spider mite and European red mite were investigated. The daily consumption rates varied from 1–2 green apple aphids forHyaliodes vitripennis Say andCampylomma verbasci Meyer to 7–9 aphids forDeraeocoris fasciolus Knight andLepidopsallus minisculus Knight.H. vitripennis consumed significantly more mites than the other mirid species with 26 and 18 mites per day for the two-spotted spider mite and the European red mite respectively. The combined use ofH. vitripennis andL. minisculus is suggested for the control of phytophagous mites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02372429
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  • 9
    Electronic Resource
    Electronic Resource
    Parasitism ofLygus lineolaris eggs onCoronilla varia, solanum tuberosum, and three host weeds in southeastern Québec (1992)
    Springer
    BioControl 37 (1992), S. 515-523 
    Details
    ISSN: 1573-8248
    Keywords: egg parasitoids ; Mymaridae ; Scelionidae ; Miridae ; Lygus lineolaris ; oophage ; parasitoïde ; Lygus lineolaris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Le parasitisme des œufs deLygus lineolaris par trois espèces deMymaridae, Anaphes iole, Erythmelus miridiphagus etPolynema pratensiphagum et une espèce deScelionidae, Telenomus sp. a été observé à Ste-Anne-de-Bellevue, Québec. Le niveau maximal de parasitisme observé au champ pour chaque espèce a été respectivement de 15,4, 53,8, 70,0 et 16,7%. Les parasitoïdes étaient obtenus d'œufs deL. lineolaris insérés dans des tiges et des branches d'Amaranthus retroflexus, Chenopodium album, Coronilla varia, Rumex obtusifolius etSolanum tuberosum. A. retroflexus etS. tuberosum portaient une population élevée deL. lineolaris et le parasitisme des œufs était suffisamment élevé pour que l'on puisse considérer qu'il constitue un facteur important de limitation des populations de la punaise.
    Notes: Abstract Parasitism ofLygus lineolaris (Palisot de Beauvois) eggs by three species ofMymaridae, Anaphes iole Girault,Erythmelus miridiphagus Dozier andPolynema pratensiphagum Walley and one species ofScelionidae, Telenomus sp., was investigated at Ste-Anne-de-Bellevue, Québec. The maximum level of field parasitism ofL. lineolaris eggs by individual species was 15.4, 53.8, 70.0 and 16,7%, respectively. Parasitoids were retrieved from eggs ofL. lineolaris inserted in stems and branches ofAmaranthus retroflexus L.,Chenopodium album L.,Coronilla varia L.,Rumex obtusifolius L. andSolanum tuberosum L. Amaranthus retroflexus andS. tuberosum sustained a large population ofL. lineolaris and egg parasitism was high enough to consider it as a potential control factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02372321
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  • 10
    Electronic Resource
    Electronic Resource
    Consumption of carrot weevil,Listronotus oregonensis, [Coleoptera: Curculionidae] by four species of carabids on host plants in the laboratory (1990)
    Springer
    BioControl 35 (1990), S. 57-60 
    Details
    ISSN: 1573-8248
    Keywords: predation ; Carabids ; carrot weevil ; prédation ; Carabidae ; charançon de la carotte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Résumé Quatre espèces de Carabidae,Anisodactylus santaecrucis, Bembidion quadrimaculatum oppositum, Pterostichus lucublandus, etPterostichus melanarius, abondantes dans les champs de carottes du sud-ouest du Québec, ont été testées en laboratoire comme prédateurs du charançon de la carotte,Listronotus oregonensis. L'espèce de Carabidae la plus grande,P. melanarius, a consommé le plus grand nombre de larves et de pupes du charançon de la carotte.B. quadrimaculatum oppositum n'a pas dévoré d'œufs de charançon lorsque ces derniers étaient pondus sur des feuilles de carottes.
    Notes: Abstract Four carabid species,Anisodactylus santaecrucis, Bembidion quadrimaculatum oppositum, Pterostichus lucublandus andPterostichus melanarius, abundant in carrot fields in southwestern Quebec, were tested for predation against the carrot weevil,Listronotus oregonensis, on host plants. The largest species,Pterostichus melanarius, consumed the greatest number of carrot weevil larvae and pupae.Bembidion quadrimaculatum oppositum did not prey on carrot weevil eggs laid on carrot leaves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02374301
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