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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 18 (1992), S. 322-326 
    ISSN: 1432-1238
    Keywords: Body water ; Bioimpedance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To evaluate the relationship between changes in body bioelectrical impedance (BI) at 0.5, 50 and kHz and the changes in body weight, as an index of total body water changes, in acutely ill surgical patients during the rapid infusion of isotonic saline solution.Design: Prospective clinical study.Setting: Multidisciplinary surgical ICU in a university hospital.Patients: Twelve male patients treated for acute surgical illness (multiple trauman=5, major surgeryn=7). Selection criteria: stable cardiovascular parameters, normal cardiac function, signs of hypovolemia (CVP≤5 mmHg, urine ouput 〈1 ml/kg×h).Interventions: After baseline measurements, a 60 min fluid challenge test was performed with normal saline solution, 0.25 ml/kg.Measurements and results: Body weight (platform digital scale), total body impedance (four-surface electrode technique; measurements at 0.5, 50 and 100 kHz) and urine output. Fluid retention induced a progressive decrease in BI at 0.5, 50 and 100 kHz, but the changes were significant for BI 0.5 and BI 100 only, from 40 min after the beginning of the fluid therapy onwards. There was a significant negative correlation between changes in water retention and BI 0.5, with individual correlation coefficients ranging from −0.72 to 0.95 (p〈0.01–0.0001). The slopes of the regression lines indicated that for each kg of water change, there was a mean decrease in BI of 18 ohm, but a substantial inter-individual variability was noted.Conclusion: BI measured at low frequency can represent a valuable index of acute changes in body water in a group of surgical patients but not in a given individual
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 16 (1993), S. 180-185 
    ISSN: 1435-0130
    Keywords: Cerium nitrate ; Toxicity ; Absorption ; Burn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this publication we present the results of three studies concerning the toxicity and absorption of cerium. In the first experimental study in rats, following the application of a 2.2% solution of cerium nitrate on dorsal wounds for five weeks, delayed healing was demonstrated and histological examination revealed richly vascularized granulation tissue in which microcalcifications and foreign-body type giant cells were found. A high concentration of cerium was found in the liver. The second experimental study employing rat enterocytes demonstrated an immediate cellular toxicity after exposure to a 2.2% cerium nitrate solution. Correction of pH and/or osmolarity did not play a protective role. In the clinical evaluation, significant levels of cerium were found in six blood samples and four urinary specimens, following the application of a 2.2% cerium nitrate solution on burn wounds. Liver biopsies were performed in two cases. There were no abnormal histological findings, but cerium levels were elevated.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 16 (1993), S. 298-302 
    ISSN: 1435-0130
    Keywords: Recombinant human erythropoietin ; Reticulocytogenesis ; Burns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to evaluate the effect of recombinant human erythropoietin on burn patients. The pilot study has shown that epoietin medication is harmless. As expected, it activated reticulocytogenesis. But epoietin did not reduce the need for homologous blood substitution.
    Type of Medium: Electronic Resource
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