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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the cytotoxicity and DNA-damaging properties of 2,4-D and U 46 D Fluid (dimethylammonium salt of 2,4-D) (1990)
    Springer
    Archives of toxicology 64 (1990), S. 497-501 
    Details
    ISSN: 1432-0738
    Keywords: 2,4-D-U 46 D Fluid ; Molecular structure ; Cytotoxicity ; DNA strand breaks
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract U 46 D Fluid (the dimethylammonium salt of 2,4-dichlorophenoxyacetic acid in a commercial formulation) was more toxic to human fibroblasts than 2,4-dichlorophenoxyacetic acid (2,4-D). Moreover, U 46 D Fluid induced single-strand breaks at apurinic/apyrimidinic (AP) sites of heat-acid treated PM2 DNA while 2,4-D did not. The1H-NMR spectrum of the dimethylammonium (DMA) salt of 2,4-D indicated the formation of a complex via a six-membered aggregate of the DMA ion and the acid group of 2,4-D. The role of complex formation of the DMA salt of 2,4-D as a cause of single-strand breaking activity and increased cytotoxicity is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977633
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Reproducibility of quantitative hexakis-2-methoxyisobutylisonitrile single photon emission tomography in stable coronary artery disease (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 17-22 
    Details
    ISSN: 1619-7089
    Keywords: Technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi) ; Quantitative single photon emission tomography (SPET) ; Inter-observer reproducibility ; Coronary disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The quantification of myocardial perfusion abnormalities is necessary to allow comparison of repeated studies, especially in the evaluation of the success of medical, interventional or combined treatment in stable coronary artery disease or in evolving myocardial infarction. The purpose of this study was to assess inter-observer reproducibility of tomographic study processing using a semi-automatic quantitative programme. Technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi) was chosen for tomographic imaging of repeated rest-stress studies in patients with stable coronary artery disease. The quantification was performed using a modification of the Cedars polar coding and comparison with the normal data base. The perfusion defects were quantified separately for each standard perfusion area [left anterior descending (LAD), right coronary (RCA) and left circumflex (LCX) arteries] and total area of hypoperfused myocardium. The inter-observer variability for 40 tomographic studies was accomplished. The defects were the largest in the LAD perfusion area (average 19.7% of the normalized LAD supply area) with an inter-observer correlation of 0.84 for this region. The greatest variability was found for the LCX region (r=0.55) and is attributed to a small average perfusion defect (7.1%), only 18 studies having abnormal perfusion in this area. In total, an average 14.3% of the left ventricular myocardium was significantly hypoperfused, and the inter-observer correlation was 0.87. These results show good inter-observer reproducibility using semi-automatic quantitation of perfusion defects. Careful interpretation of smaller defects in the evaluation of treatment results is advised when repeated 99mTc-Sestamibi single photon emission tomography studies are processed by more than one observer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177679
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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