ISSN:
1432-1041
Keywords:
Parkinson's disease
;
Apomorphine
;
pharmacokinetics
;
adverse effect
;
on-off effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00626377
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