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  • 1990-1994  (7)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of alveolar bone loss in beagles with the NSAID naproxen (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 26 (1991), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The non-steroidal anti-inflammatory drug(NSAID) naproxen was studied in 11 beagle dogs over a 13-month period to determine its effect on the progression of periodontitis. Following a 6-month pretreatment period, 5 dogs received naproxen daily at a dosage of 2.0 mg/kg for 1 month, then 0.2 mg/kg for 6 months. Six control dogs received a gelatin capsule daily as placebo. Standardized radiographs were used to measure the rate of bone loss during the pretreatment and treatment periods. In the control dogs, the rate of bone loss was seen to increase during the treatment period although the increase was not statistically significant. In dogs treated daily with naproxen, the rate of bone loss in the treatment period was significantly less at 4 months of treatment; however, at 7 months the difference, though lower than pretreatment rate, was not significant. When the percent change in rate of bone loss during the overall 7-month treatment period was compared with pretreatment rate, the control dogs demonstrated a 38% increase in rate of bone loss during the treatment period contrasting with a 61% decrease in bone loss rate in naproxen-treated dogs. The data indicate that the non-steroidal anti-inflammatory drug naproxen can significantly inhibit alveolar bone loss in beagles. At 4 months of treatment the rate of bone loss in the naproxen-treated dogs was significantly less than pretreatment, but at 7 months of treatment the rate was no longer statistically significantly less than baseline. This probably reflects a dose response to naproxen treatment for, after 30 days of the treatment period, the naproxen dosage was reduced 10-fold due to tolerance by the beagle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1991.tb01801.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Use of digital radiography to demonstrate the potential of naproxen as an adjunct in the treatment of rapidly progressive periodontitis (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 26 (1991), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of the non-steroidal anti-inflammatory drug, naproxen, in reducing periodontal disease activity was assessed in 15 patients with rapidly progressive periodontitis. All patients in this double-blind study were treated with scaling and root planing. Thereafter, 7 patients receiving 500 mg naproxen b.i.d. for 3 months, and 8 patients received placebo. Disease activity was assessed in three ways. First, alveolar bone height was determined using standardized radiography. Second, alterations in alveolar bone metabolism were assessed using 99m-Tc-methylene diphosphonate uptake prior to dosing and 3 months later. Finally, bone loss or gain was detected using digital subtraction radiography. In this study, conventional subtraction images were processed to isolate the area of change and superimpose the change on the original radiograph. This allowed determination of both the direction and location of osseous changes. There was significantly less bone loss as determined by analysis of bone height during the 3-month study in the naproxen-treated patients when compared to the placebo-treated patients (p 〈 0.001). Radiopharmaceutical uptake was significantly reduced in the alveolar bone in patients receiving naproxen (p 〈0.03), whereas no significant change was observed in the placebo-treated patients. Furthermore, the subtraction radiographs showed a significant increase in the proportion of teeth demonstrating bone gain in the naproxen-treated group. These findings indicate that naproxen may be a useful adjunct to scaling and root planing in patients with rapidly progressive periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1991.tb01731.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 27 (1992), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This investigation focuses on the changes in the concentrations of cyclooxygenase (CO) products present within the crevicular fluid in naturally-progressing periodontitis in the beagle and the effects of various non-steroidal anti-inflammatory drugs (NSAIDs) on these metabolite levels and disease progression. Six groups of 5–6 beagles with periodontitis were followed for 6 months to determine the pretreatment rate of radiographic bone loss. At baseline, groups of animals were placed on soft chow to promote disease progression. Groups were treated with either placebo, three different formulations of systemic ibuprofen, systemic naproxen or topical flurbiprofen. During the 6-month treatment phase, crevicular fluid (CF) samples and radiographs were taken at regular intervals. Radioimmunoassay of CF samples from untreated animals demonstrated a steady increase in prostaglandin E2 (PGE 2) over baseline values. At 1 month, CF-PGE2 levels increased 2-fold over baseline and, by 6 months, had reached a 5- to 6-fold elevation. Crevicular fluid thromboxane B2 (CF-TxB2) levels rapidly reached a 4- to 5-fold peak over baseline at 1 month and subsequently dropped to a 2-fold elevation for the remainder of the study. The rate of bone loss (BLOSS) in untreated animals increased 38% during the 6-month period, as compared to baseline pretreatment BLOSS rates. Overall, there was a significant depression in the CF levels of both PGE2 and TxB2 in all NSAID-treated groups. All NSAID treatments significantly retarded BLOSS, ranging from 21.0–36.9% of the control BLOSS rate. The topical application of flurbiprofen was as effective in depressing CF levels of PGE2 and TxB2 as systemic or sustained release formulations of other NSAIDs. The data further substantiate the concept that much of the BLOSS that occurs in periodontal disease is mediated by products of the cyclooxygenase pathway. Furthermore, CO activation represents a major regulatory step in bone destruction and may thereby serve as an important site for pharmacological modulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1992.tb01670.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Efficacy of meclofenamate sodium (Meclomen®) in the treatment of rapidly progressive periodontitis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 20 (1993), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract This 6-month, double-blind, controlled clinical trial determined the efficacy of the non-steroidal anti-inflammatory drug, meclofenamate sodium (Meclomen®), as an adjunct to scaling and root planing in the treatment of rapidly progressive periodontitis (RPP). 22 subjects (7 male. 15 female) aged 36.5±7.88 years with RPP and disease-active sites as determined by pretreatment bone scan had standardized radiographs at baseline and 6 months, and clinical measurements at baseline, 3 and 6 months. Following full-mouth scaling and root planing, subjects were randomly assigned to either a placebo, 50 or 100 mg meclofenamate sodium bid group. Bone change over the 6-month period as assessed by subtraction radiography was the primary efficacy determinant. Specialized software was used to isolate the lesion from the subtraction image and to measure bone change along the root surface. ANOVA using the subject as the unit of analysis revealed a significant dose response (P〈0.001) with the placebo group having a mean bone loss of 0.42±0.06 mm and the low and high dose groups having mean bone gains of 0.07±0.05 and 0.20±0.07 mm, respectively. These findings indicate that meclofenamate sodium may be a useful adjunct in the treatment of rapidly progressive periodontitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1993.tb00708.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A comparison of the diagnostic advantages of panoramic radiography and computed tomography scanning for placement of root form dental implants (1994)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 5 (1994), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study evaluated the advantages of computed tomography (CT) in comparison to routine panoramic radiography for dental implant treatment planning. An in vitro validation study was performed to assess the accuracy of CT and panoramic radiography film images for measurement of anatomic structures and distances between anatomic structures. After correcting by a standard 25% magnification on the panoramic images, a significant difference in measurements was found between the CT and panoramic radiography images. Ten subjects requiring implants in compromised ridges were treatment planned with either CT and panoramic radiographs or panoramic radiographs alone. The ideal implant length was determined at surgery with direct digital radiography. The dentists were significantly more confident using CT and panoramic images than panoramic radiographs alone. Implant length treatment planned with panoramic radiography alone underestimated length significantly compared with the implant length determined to be ideal during surgery.whereas treatment planning with CT and panoramic radiography demonstrated no significant difference. The data indicate the CT may be of value in treatment planning for dental implants, especially when gaining maximum length is of critical importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1994.050406.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative digital subtraction radiography for the assessment of peri-implant bone change (1992)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 3 (1992), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to develop a digital subtraction technique to assess periimplant bone change. The method uses subtraction radiography to enhance visualization of the area of change that has occurred between radiographic examinations, and superimposes the area of change on the original radiographs. Furthermore, a reference wedge allows calculation of the mass of the lesion. The method was validated using 21 small bony chips placed on 3 different skulls prior to the first radiograph. The chips were removed, a second radiograph taken, and the images subtracted. A morphologic method was used to isolate the lesion and the change in bone mass calculated. Overall, there was excellent correlation between the calculated lesion mass (mg) and actual lesion mass (r²〉0.90). The utility of the method was demonstrated using a case that experienced implant failure. These data indicate that quantitative digital subtraction radiography may be of value in measuring peri-implant 1 bone change in root form implants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1992.030104.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    A semi-automated computer-assisted method for measuring bone loss adjacent to dental implants (1992)
    Copenhagen : Munksgaard International Publishers
    Clinical oral implants research 3 (1992), S. 0 
    Details
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to develop a repeatable method for measurement of bone support around root form and blade implants suitable for use in high-quality but unstandardized radiographs. 10 phantoms were fabricated to simulate progressive osseous defects around implants. Radiographs were taken in triplicate and digitized. Specialized software was written which placed a grid of known dimensions over the implant so that the top and the bottom of the grid were at the neck and the base of the implant, respectively. The investigators selected the edge of the bone at each point where the grid intersected the implant and the software automatically detected the implant edge. The software also outlined and displayed the defect on the computer monitor. Measurements were performed 5 times and the standard deviation was taken as a measure of the repeatability of the method. Repeatability for blades and root forms was 0.19 ± 0.07 mm and 0.08 ± 0.03 mm, respectively. There was no significant difference in the ability to measure bone loss in the blade versus the root form (pequals;0.17, NS). These results indicate that this semi-automated computer-assisted method for measuring bone loss around implants is repeatable and may be of value for clinical trials using either root form or blade implants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0501.1992.030105.x
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    Paper (German National Licenses)
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