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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 30 (1992), S. 349-367 
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 36 (1992), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have defined a strategy for the development of a T-cell vaccine for blood stage immunity, taking into consideration the central role of T cells and MHC restriction in malaria immune responses. We have used the AMPHI computer algorithm lo identify putative T-cell epitopes from conserved regions of 11 Plasmodium falciparum asexual stage proteins. Ten of the eleven proteins arc currently candidates for vaccine development. Using this algorithm we selected 22 putative T-cell epitope peptides und 8 control peptides. These peptides were used to test the T-cell responses of three defined populations of Caucasians who have (1) recovered from P. falciparum malaria. (2) been exposed, but never clinically infected, (3) never been exposed or infected. Preliminary analysis of our data shows population differences in T-tell responses to putative T-cell epitope peptides. Ultimately, these studies will help to identify those T epitopes that can be incorporated into a T-cell vaccine for protective immunity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: Rabbits ; diabetes ; hypercholesterolaemia ; lipoproteins ; cholesterol metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum lipoproteins and key hepatic and intestinal enzymes regulating cholesterol synthesis, esterification and catabolism, namely 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, acyl coenzyme A: cholesterol-o-acyltransferase (ACAT) and cholesterol 7α-hydroxylase respectively, were compared in two hypercholesterolaemic rabbit models — the cholesterol-fed animal and the hypercholesterolaemic diabetic animal. Hypercholesterolaemia in the cholesterol-fed animals was reflected in the VLDL and LDL fractions, whereas VLDL and HDL2 cholesterol levels were elevated in the diabetic animals. The lipoproteins of the cholesterol-fed animals were enriched with cholesterol but the lipoprotein fractions in the diabetic animals were enriched with triacylglycerol. While hepatic HMGCoA reductase activity was significantly reduced in both groups, the activities of hepatic ACAT and cholesterol 7α-hydroxylase were significantly increased in the cholesterol-fed animals and significantly reduced in the diabetic animals compared with controls. In the intestine, the activity of HMGCoA reductase was increased and ACAT reduced in the diabetic animals. By contrast, in the cholesterol-fed group, HMGCoA reductase activity was lower and ACAT activity was higher in comparison with the control group. These differences in lipoproteins and cellular cholesterol metabolism between the hypercholesterolaemic rabbit models may explain the differences in susceptibility to atherosclerosis, previously reported in these two animal models.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-5036
    Keywords: nutrient cycling ; plant-soil interactions ; spatial variability ; topographic patterns ; tropical forest ecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Soils and forest floor were sampled quantitatively from a montane wet tropical forest in Puerto Rico to determine the spatial variability of soil nutrients, the factors controlling nutrient availability to vegetation, and the distribution of nutrients in soil and plants. Exchangeable cation concentrations were measured using different soil extracting procedures (fresh soil with NH4Cl, air-dried and ground soil with KCl, and a Modified Olsen solution) to establish a range of nutrient availability in the soil, and to determine the relationship between different, but commonly used laboratory protocols. The availability of exchangeable Ca, Mg, and K was significantly lower in soils extracted fresh with NH4Cl than from soils which were dried and ground prior to extraction with KCl or a modified Olsen solution. Soil nutrient availability generally decreased with depth in the soil. Several soil properties important to plant growth and survival varied predictably across the landscape and could be viewed in the context of a simple catena model. In the surface soils, exchangeable base cation concentrations and pH increased along a gradient from ridge tops to riparian valleys, while soil organic matter, exchangeable Fe and acidity decreased along this gradient. On the ridges, N, P, and K were positively correlated with soil organic matter; on slopes, N and P were positively correlated with organic matter, and Ca, Kg, and pH were negatively correlated with exchangeable Fe. Nutrient availability in the upper catena appears to be primarily controlled by biotic processes, particularly the accumulation of organic matter. The Ca, K, and P content of the vegetation was higher on ridges and slopes than in the valley positions. Periodic flooding and impeded drainage in the lower catena resulted in a more heterogeneous environment. A comparison of the Bisley, Puerto Rico soils with other tropical montane forests (TMF) revealed that the internal heterogeneity of soils in the Bisley Watersheds is similar to the range of average soil nutrient concentrations among TMF's for Ca, Mg, and K (dry/ground soils). Phosphorus tended to be slightly higher in Bisley and N was lower than in other TMFs.
    Type of Medium: Electronic Resource
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