ISSN:
1471-4159
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
Abstract: One of the major clinical findings in Alzheimer's disease (AD) is the formation of deposits of β-amyloid protein in amyloid plaques, derived from the β-amyloid precursor protein (β-APP). To determine the possible use of β-APP as a diagnostic marker for AD in CSF, a monoclonal antibody-based immunoassay specific for this protein was developed. The assay does not differentiate between β-APP695 and β-APP751 forms but does preferentially recognize β-APP751 complexed with a protease. Of the two sets of CSF samples tested, one set, obtained from living patients, gave a slightly lower level of β-APP in AD and Parkinson's disease patients relative to controls, whereas the other set, composed of postmortem samples, showed no significant differences between the AD and control groups.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1471-4159.1991.tb02026.x
Permalink