Electronic Resource
Springer
Inflammation research
38 (1993), S. C292
ISSN:
1420-908X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of histamine, H1 and H2 agonists on the transmembrane action potentials (APs) of electrically driven left auricle of guinea-pig were studied in Tyrode and in 25 mM K+ Tyrode solution. Under physiological conditions, histamine (10−7−10−5 M) increased the amplitude and the plateau phase of AP. The H1 agonist pyridylethylamine (PEA; 10−5−10−4 M) exerted similar effects as histamine while the H2-agonist impromidine (10−8−10−7 M) decreased the duration of AP. PEA restored the abolished electromechanical activity in high K+ (25 mM)-depolarized atria. These slow APs were unaffected by the β-adrenergic blocker pindolol (5×10−7 M) but were abolished by the H1 antagonist mepyramine (10−5 M). Neither dimaprit nor impromidine was able to induce slow AP. Our results suggest that in guinea-pig left atria histamine enhances the slow inward Ca2+ current mediated by H1 receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01996490
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