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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 27 (1994), S. 4106-4113 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 27 (1994), S. 4114-4126 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Infection 18 (1990), S. 53-56 
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Staphylococcus aureus ist in der Regel der erste bakterielle Erreger, der bei Patienten mit zystischer Fibrose in den Atemwegssekreten nachgewiesen wird. In der folgenden Übersicht wird diese Beziehung zwischen Wirtsorganismus und Besiedler nach dem neuesten Forschungsstand zur Toxizität des Erregers, Mechanismen der Atemwegsschädigung, Therapie und Prävention dargestellt. Nach neuesten Forschungsergebnissen spielt die Virusinfektion für die initiale Schädigung des Atemwegsepithels eine Rolle, die Staphylokokken-Kolonisation folgt nach. Die persistierende Kolonisation mit diesem Erreger wird unterhalten durch die Affinität der Staphylokokken zum Schleim bei zystischer Fibrose, durch mukoziliare Störungen und weitere unbekannte Faktoren. Daraus entwickelt sich eine fortschreitende Schädigung der Lungen, Einflüsse auf die Pseudomonas-Infektion sind möglich. Die überwiegende Zahl der verfügbaren Forschungsergebnisse spricht dafür, daß in allen Stadien der bronchopulmonalen Infektion bei zystischer Fibrose eine aggressive antimikrobielle Therapie gegenS. aureus erforderlich ist. Weitere Maßnahmen zur Verhütung der Kolonisation und der toxischen und immunpathogenetischen Folgen der Staphylokokken-Infektion sind ebenfalls wichtig. In einer derzeit laufenden Studie wird die Antibiotkaprophylaxe in frühe Stadien der zystischen Fibrose geprüft. Andere Strategien wie Vakzinen, Antitoxine, entzündungshemmende Substanzen, Immunmodulatoren und Antibiotikaregime müssen wissenschaftlich geprüft werden.
    Notes: Summary Staphylococcus aureus is usually the first bacterial pathogen detected in the respiratory secretions of patients with cystic fibrosis. This review briefly examines the characteristics of this host-parasite relationship in terms of current knowledge about the toxicity of the organism, mechanisms of respiratory tract injury, therapy and prevention. Recent evidence indicates that viral infection plays a role in the initial damage of the respiratory epithelial cells and staphylococcal colonization ensues. Affinity of staphylococcus for cystic fibrosis mucus, mucociliary abnormalities and unknown factors contribute to persistent colonization with this organism causing progressive pulmonary damage and possibly influencing Pseudomonas infection. Most of the evidence today indicates that aggressive antibiotic management directed againstS. aureus is warranted in all stages of bronchopulmonary infection in cystic fibrosis. Future efforts to prevent colonization and the toxic and immunopathic consequences of staphylococcal infection are also important. One study is in progress that examines antibiotic prevention in the early stages of cystic fibrosis. Future investigations need to address other strategies including vaccines, antitoxins, anti-inflammatory agents, immunomodulators, and antibiotic regimens.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Plant molecular biology 24 (1994), S. 203-207 
    ISSN: 1573-5028
    Keywords: trichome ; plant development ; Myb ; transcription factor ; cell expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A genomic clone containing the gl1–2 allele has been isolated and sequenced. The predicted amino acid sequence of the gl1–2 protein is identical to that of the GL1-Col allele up to position 201. At this point in the coding region of gl1–2 there is a deletion relative to the wild-type sequence that results in an in-frame stop codon at position 202. This deletion removes 27 amino acid residues, including a highly negatively charged region, from the predicted gl1–2 polypeptide. The loss of this negatively charged carboxy-terminal region from the gl1–2 product is most likely the cause of the partial loss of gene activity which results in a reduction in leaf trichome initiation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of plastic surgery 16 (1993), S. 70-72 
    ISSN: 1435-0130
    Keywords: Acne keloidalis ; Tissue expansion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acne keloidalis is an uncommon disease that predominantly affects post-pubertal males. The condition is primarily a chronic folliculitis complicated by hypertrophic scarring and multiple draining abscesses. Many patients present with advanced stages, despite prolonged non-operative treatments. Advanced stages of the disease can be easily treated with excisional cure followed by primary closure. Tissue expansion of the posterior scalp is a treatment option in very large lesions, yet simple primary closure offers an equally successful cosmetic and functional result, in lesions up to 11.5 cm in width.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1885-1891 
    ISSN: 0887-624X
    Keywords: copolycarbonate ; bisphenol A ; tetrabromobisphenol A ; end group ; analysis ; properties ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The types and concentrations of end groups present in bisphenol A-tetrabromobisphenol A copolycarbonates (BA-TBBA coPCs) have major effects on the copolymer solution washability and thermal stability. Six types of coPC end groups are possible: two by monophenol capping of each comonomer, two phenolics (BA-OH and TBBA-OH), and two carbamates (one from each comonomer). BA-TBBA coPCs were prepared by typical solution and interfacial methods and their phenolic and carbamate end group concentrations were correlated with their solution washability and thermal discoloration. Both phenolic and carbamate end groups proved deleterious to these two copolymer properties. An improved interfacial process that employs 4-N,N-dimethylaminopyridine as the coupling catalyst provides coPCs having low concentrations of phenolic and carbamate end groups and that, therefore, wash without emulsification and are thermally stable. © 1994 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 52 (1994), S. 1809-1814 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The physical, thermomechanical, and rheological properties of bisphenol A-tetrabromobisphenol A copolycarbonates (BA-TBBA coPCs) were studied as a function of copolymer composition. TBBA carbonate segments in the copolymer induce proportionally increased glass transition temperatures, heat distortion temperatures, ignition resistance, tensile and flexural moduli, and density. Properties that do not change proportionately with copolymer composition are coefficient of linear thermal expansion, ambient notched Izod and dart puncture impact strengths, and refractive index. Many properties of BA-TBBA coPCs, including glass transition temperature, heat distortion temperature under load, and modulus, approach those of amorphous high-performance thermoplastics such as polyetherimide and polyethersulfone. However, these copolymers have the possible advantage of melt blending with bisphenol A polycarbonate to form homogeneous alloys with variable and controllable properties. © 1994 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 52 (1994), S. 467-481 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The chain sequence architecture of bisphenol A-tetrabromobisphenol A copolycarbonates depends on the process employed to prepare them. An interfacial process involving a single-step phosgenation produces a segmented block copolymer, contrary to previous assumptions. An interfacial two-step phosgenation process allows the preparation of random copolycarbonates. In each process the control of the pH of the acqueous phase of the two phase reaction mixture is required to achieve complete comonomer conversion to copolymer and to obtain the desired sequence architecture. The chain sequence architecture of these copolycarbonates can be estimated by examination of their Fourier transform infrared spectra. The relative bandwidth of the carbonate stretching band is roughly proportional to the copolycarbonate number average sequence length, allowing the facile distinction between block and random copolymers. The number average sequence lengths of these copolycarbonates were quantified by carbon-13 NMR spectroscopy. These analyses showed that the one-step phosgenation process yields segmented block copolycarbonates having number average sequence lengths from about 4 to 9, and the two-step phosgenation process produces random copolycarbonates having sequence lengths from 1.6 to 2. The distribution of the aromatic carbon triads of these random copolymers shows them to have an alternate-segmented block architecture, which is consistent with the synthesis conditions, rather than a statistically random distribution of comonomer segments. Dynamic mechanical analysis of two of these copolycarbonates shows a dependence of their low temperature secondary transitions on the copolymer sequence structure. A segmented block copolycarbonate, having a number average sequence length of about 4, displays two distinct peaks in its tan δ curve at temperatures corresponding to those transitions observed in the respective homopolymers. The tan δ curve of a random copolycarbonate shows a single low temperature secondary transition midway between those of the homopolymer. © 1994 John Wiley & Sons, Inc.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 1058-1060 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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