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  • 1
    Electronic Resource
    Electronic Resource
    Immunopathology of Ulcer Disease (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 697 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb49939.x
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  • 2
    Electronic Resource
    Electronic Resource
    Importance of cytotoxic T lymphocytes in the rejection of transplanted hepatocellular carcinoma (1994)
    Springer
    Journal of gastroenterology 29 (1994), S. 282-288 
    Details
    ISSN: 1435-5922
    Keywords: hepatoma model ; cytotoxic T lymphocyte ; NK cell ; cancer immunity ; immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fischer rats became resistant to syngeneic hepatocellular carcinoma (FAA-HTC1) cells on repeated sensitization with mitomycin C-treated FAA-HTC1 cells. In contrast, FAA-HTC1 cells injected into the liver killed normal control Fischer rats within 2 months. Histopathological studies revealed massive accumulation of mononuclear cells in the tumor tissues of sensitized rats that rejected syngeneic FAA-HTC1 cells, whereas very few mononuclear cells were found in the tumor tissues of control rats. Cell populations infiltrating the tumor tissues were identified by flow cytometric analysis. Mononuclear cells found within the regressing tumors of the sensitized rats were identified as mostly T cells, and two-thirds of these T cells were CD8-positive. Compared with the activity in control rats, the killer activity of mononuclear cells infiltrating tumors was significantly increased in the sensititized rats 7 days after tumor inoculation. Depletion of CD8(+) T cells significantly reduced the cytotoxicity of mononuclear cells infiltrating tumors obtained from sensitized rats. In contrast, depletion of CD16(+) cells reduced the cytotoxicity of mononuclear cells infiltrating tumors obtained from both control and sensitized rats. Furthermore, the CD16(+) cell-depleted fraction of mononuclear cells infiltrating tumors showed significant cytotoxicity against FAA-HTC1 cells, but failed to show cytotoxicity against other syngeneic tumor cells or allogeneic hepatoma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02358366
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence that gastric antisecretory action of lipopolysaccharide is not due to a toxic effect on gastric parietal cells (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1039-1044 
    Details
    ISSN: 1573-2568
    Keywords: endotoxin ; gastric acid secretion ; gastric parietal cell ; interleukin-1 ; lipopolysaccharide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently found that bacterial lipopolysaccharide (LPS) or endotoxin at minute doses inhibits the secretion of gastric acid and pepsin in rats. The present study was performed to determine whether this antisecretory action of LPS was a reversible biological response or a result of the destruction of gastric parietal cells by endotoxin. The intraperitoneal injection of LPS into pylorus-ligated rats resulted in a dose-related (40–4000 ng/kg) decrease in gastric acid secretion, with maximal inhibition being observed at a dose of 4000 ng/kg. The stomach then was examined both macroscopically and microscopically for the presence or absence of mucosal lesions or damaged gastric parietal cells. No morphological changes in the gastric mucosal, structure including parietal cells were observed even in the rats injected with 4000 ng/kg of LPS. Next, basal gastric acid output was compared in the rats that had received LPS (4000 ng/kg, intraperitoneal) or saline alone 24 hr before. There was no significant difference in gastric, acid secretion between the saline- and LPS-pretreated groups, indicating that the secretory capacity of gastric parietal cells returned to the control level at 24 hr after the injection of a maximal antisecretory dose of LPS. These results clearly suggest that the LPS-induced inhibition of gastric secretion results not from its toxic or destructive effect on the gastric secretory mechanism but from its reversible biological effect on gastric physiology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01300284
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  • 4
    Electronic Resource
    Electronic Resource
    An ultrastructural study of primary granule subtypes in human neutrophils from chronic myeloproliferative disorders (1994)
    Springer
    Medical molecular morphology 27 (1994), S. 99-112 
    Details
    ISSN: 1860-1499
    Keywords: Primary granule subtype ; Chronic neutrophilic leukemia ; Chronle myeloproliferative disorder ; Human neutrophil ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The bone marrow of 17 patients with chronic myeloproliferative disorders (CMPDs) was investigated by electron microscopy. Three subtypes of primary granules, i.e., parallel tubular granules (PTGs), fibrillar granules (FGs), and periodic lamellar granules (PLGs), were found in neutrophils from the CMPDs. Only one case of chronic neutrophilic leukemia (CNL) showed PTGs. Both FGs and PLGs were found in various CMPDs in varying frequencies. These granules tested positive for myeloperoxidase, and were seen primarily in immature neutrophils. In addition, the presence of hybrid FG/PTG granules and hybrid FG/PLG granules was confirmed. These results suggest that PTGs, FGs, and PLGs represent subtypes of primary granules, and that a close association exists between them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348175
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