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  • 1990-1994  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Detection ofToxoplasma gondii in AIDS patients by the polymerase chain reaction (1993)
    Springer
    Infection 21 (1993), S. 150-153 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei AIDS-Kranken stellt die Toxoplasmose eine der häufigsten lebensbedrohlichen Infektionen dar. Wegen des geringen prädiktiven Wertes der Serologie ist die Diagnose im Zustand der Abwehrschwäche trotz konsequenter klinischer Kontrollen und wiederholter Laboruntersuchungen schwierig. Die vorliegende Studie wurde durchgeführt, um die Methoden der konventionellen Diagnostik mit der Polymerasekettenreaktion (PCR) zu vergleichen und den Nutzen der PCR in der Toxoplasmose-Diagnostik zu beurteilen. Die PCR wurde bei 11 unausgewählten AIDS-Kranken eingesetzt; für die Untersuchungen standen 12 Proben (Liquor cerebrospinalis, bronchoalveoläre Lavage-Flüssigkeit, eine Hirnbiopsie und eine Leberbiopsie) zur Verfügung. Die Ergebnisse zeigten bei acht der 11 Patienten eine gute Korrelation zwischen den klassischen Nachweismethoden und der PCR. Sie bestätigen den Wert der Bronchoalveolar-Lavage für den Nachweis der Toxoplasmose bei AIDS-Kranken. Die pathophysiologische Bedeutung der Toxoplasma-Organismen in den Proben wird diskutiert.
    Notes: Summary In recent years, toxoplasmosis has become one of the most frequent and life-threatening opportunistic infections in AIDS patients. Despite strict clinical follow-up and repeated biological examinations, its diagnosis remains difficult to establish in the context of immunodeficiency because of the poor predictive value of serology. The aim of the study was to compare standard methods of diagnosis with the polymerase chain reaction (PCR), in an attempt to investigate the potential usefulness of PCR in the diagnosis of toxoplasmosis. Twelve biological samples (cerebrospinal fluid, bronchoalveolar lavage fluid, one brain biopsy and one liver biopsy) from 11 unselected AIDS patients were tested by PCR. The results showed good correlation (for eight out of 11 patients) between classical methods and PCR, and confirm the value of bronchoalveolar lavage for the diagnosis of toxoplasmosis in AIDS patients. The pathophysiological significance of the presence ofToxoplasma in samples tested is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01710533
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of a new cut-off value for the diagnosis of congenital toxoplasmosis by detection of specific IgM in an enzyme immunoassay (1993)
    Springer
    European journal of clinical microbiology & infectious diseases 12 (1993), S. 396-398 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964443
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tumor necrosis factor alpha, interleukin 1 alpha, and interleukin 6 mRNA expressed by human astrocytoma cells after infection by three different strains ofToxoplasma gondii (1994)
    Springer
    Parasitology research 80 (1994), S. 271-276 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The role of cytokines in the pathogenesis of toxoplasmosis remains unknown to a large extent, especially in the case of reactivation that occurs in immunocompromised patients. To assess the importance of tumor necrosis factor alpha (TNFα), interleukin 1 alpha (IL1 α), and interleukin 6 (IL6), we studied the expression of these three cytokines by human astrocytoma cells after infection by three different strains ofToxoplasma gondii. The virulent RH strain, the intermediate 76K strain, and the cystogenic Prugniaud strain did not induce significantly different levels of expression of the cytokine messenger RNAs when the cytokines were studied at 1, 3, 6, and 24 h after parasitic infection. These results could indicate that infection byT. gondii strains of different virulence do not involve strong differences in TNFα, IL1α, or IL6 expression by human astrocytoma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02351866
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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