ISSN:
1435-1463
Keywords:
Dopamine
;
schizophrenia
;
neuroleptic response
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The purpose of this study was to evaluate the hypothesis that neuroleptic non-response in the face of “adequate” DA post-synaptic receptor blockade reflects failure of regulatory mechanisms to decrease DA pre-synaptic activity. Eight chronic schizophrenics, meeting rigorous criteria for neuroleptic non-response, were treated for four weeks with alpha-methylparatyrosine as an adjunct to their previously stable neuroleptic dose. Treatment with AMPT produced a prompt decrease in plasma HVA that was, on average, 72% lower at the end of the study. While there was also strong clinical evidence of reduction in central dopaminergic activity (both a significant reduction in dyskinetic movements and increase in extrapyramidal symptoms), there was virtually no change in severity of psychotic symptoms. Thus, in this group of non-responders, psychotic symptoms persisted despite both extensive dopamine post-synaptic receptor blockade and marked reduction of presynaptic activity. These symptoms may not be directly DA dependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01283030
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