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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of advanced nursing 15 (1990), S. 0 
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An examination was made of relationships between the physical health and mental depression of nurse shiftworkers and their scores on relevant social and work-related variables Nurses on the day, afternoon, night and rotating shifts from five hospitals (n = 463) were surveyed using a mail-back questionnaire Two alternative models were examined in the study The first model suggests that shift work influences the physical health and mental depression of nurses, which in turn affect social and work-related variables including family relations, formal and informal social participation, solitary activities, job performance, and job-related stress Shiftwork's disturbance of the body's circadian rhythm would exert a direct affect on nurses’ physical health and mental depression, which in turn would then affect other aspects of the nurses’ lives The second model suggests instead that shift work primarily affects social and work-related variables, which then influence physical health and mental depression Circadian rhythm desynchronization, while still being a consequence of shiftwork, might not directly affect physical health and mental depression Contrary to either of the two models proposed for the study, shiftwork was not found to be significantly related to either the nurses’ physical health or mental depression However, certain factors, when considered in conjunction with the unique shift-related job characteristics of nursing, may help to explain the study's unexpected findings
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0192-253X
    Keywords: Sex determination ; sexual differentiation ; reptiles ; temperature-dependent sex determination ; behavior ; steroidogenic enzymes ; aromatase ; reductase ; estrogen ; androgen ; steroid hormone receptors ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: In many egg-laying reptiles, the incubation temperature of the egg determines the sex of the offspring, a process known as temperature-dependent sex determination (TSD). In TSD sex determination is an “all or none” process and intersexes are rarely formed. How is the external signal of temperature transduced into a genetic signal that determines gonadal sex and channels sexual development? Studies with the red-eared slider turtle have focused on the physiological, biochemical, and molecular cascades initiated by the temperature signal. Both male and female development are active processes - rather than the crganized/default system characteristic of vertebrates with genotypic sex determination - that require simultaneous activation and suppression of testis- and ovary-determining cascades for normal sex determination. It appears that temperature accomplishes this end by acting on genes encoaing for steroidogenic enzymes and steroid hormone receptors and modifying the endocrine microenvironment in the embryo. The temperature experienced in development also has long-term functional outcomes in addition to sex determination. Research with the leopard gecko indicates that incubation temperature as well as steroid hormones serve as organizers in shaping the adult phenotype, with temperature modulating sex hormone action in sexual differentiation. Finally, practical applications of this research have emerged for the conservation and restoration of endangered egg-laying reptiles as well as the embryonic development of reptiles as biomarkers to monitor the estrogenic effects of common environmental contaminants. © 1994 Wiley-Liss, Inc.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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