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  • 1
    Electronic Resource
    Electronic Resource
    Hemodynamic response of a canine model of chronic heart failure to intravenous dobutamine, nitroprusside, enalaprilat, and digoxin (1993)
    Springer
    Cardiovascular drugs and therapy 7 (1993), S. 349-356 
    Details
    ISSN: 1573-7241
    Keywords: heart failure ; dobutamine ; nitroprusside ; enalaprilat ; digoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hemodynamic effects of acute intravenous administration of nitroprusside, dobutamine, enalaprilat, and digoxin was investigated in a canine model of chronic heart failure (CHF) produced by multiple sequential intracoronary microembolizations. Dobutamine (4 µg/kg/min) increased cardiac output (2.4±0.1 vs. 4.0±0.4 l/min; p〈.001) and LV ejection fraction (LVEF; 26±1 vs. 30±4%; p〈.01), and decreased systemic vascular resistance (SVR; 3620±170 vs. 2470±190 dynes sec cm−5; p〈.001). Nitroprusside (3 µg/kg/min) acted as a venodilator; it decreased pulmonary artery wedge pressure (16±1 vs. 13±1 mmHg; p〈.01) and SVR (3730±440 vs. 3210±280 dynes sec cm−5; NS) but had no effect on cardiac output. Enalaprilat (1.875 mg) produced a significant increase of cardiac output (3.0±0.5 vs. 3.8±0.5 l/min; p〈.001) and LVEF (22±1 vs. 30±1%; p〈.01), and decreased SVR (3280±400 vs. 2450±250 dynes sec cm−5; p〈.01). Intravenous digoxin at a cumulative dose of 0.75 mg increased LVEF (23±2 vs. 31±2%; p〈.01) but had no effect on SVR. These data indicate that this canine model of CHF responds to acute pharmacologic intervention in a manner comparable to that seen in patients with CHF. Accordingly, this model may be a useful tool for the preclinical evaluation of new drugs targeted toward the treatment of CHF and for investigating the mechanisms of action of drugs currently used for the treatment of this disease state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00880158
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of left ventricular function during ejection (1992)
    Springer
    Annals of biomedical engineering 20 (1992), S. 127-138 
    Details
    ISSN: 1573-9686
    Keywords: Ventricular performance ; Ventricular contractility ; Cardiac function ; Cardiac energy ; Heart ; Power
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Several ejection indices of left ventricular performance are described. The most sensitive is the rate of change of power, especially when measured at the time of peak left ventricular wall tension. When measured at peak tension, the rate of change of power reflects force-velocity-length relations and, therefore, is theoretically appealing. The rate of change of power itself incorporates terms shown to be of functional significance. Among these is the rate of change of flow. This expression is more readily measured than the rate of change of power and can be approximated noninvasively by the measurement of blood acceleration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02368509
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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