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  • 1990-1994  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Double fracture method ofin situ stress measurement in brittle rock (1992)
    Springer
    Rock mechanics and rock engineering 25 (1992), S. 89-108 
    Details
    ISSN: 1434-453X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying , Geosciences
    Notes: Summary A new technique, the Double Fracture Method ofin situ stress measurement, is described with regard to its theoretical principles and field instrumentation. The method differs from the hydraulic fracture method in that the loading fluid is prevented from penetrating into the induced fractures. In the new method, the loading pressure is raised to create a set of two mutually perpendicular microfractures on the borehole boundary. The principal stresses and their orientation in the plane normal to the borehole can be deduced from the diametral deformation of the borehole. Laboratory and field measurements validating the method are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01040514
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Characterization of glycoprotein C-negative mutants of herpes simplex virus type 1 isolated from a patient with keratitis (1990)
    Springer
    Archives of virology 113 (1990), S. 195-207 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recently three strains of herpes simplex virus type 1 (HSV-1), which did not react with MicroTrak Herpes (Syva Co.), were isolated by us from a patient with recurrent herpetic keratitis. In this study we characterized these strains of HSV-1 and found them to be HSV-1 gC− mutants which are very rare isolates from humans. The properties of the HSV-1 strains regarding plaque morphology on Vero cells and chick embryo fibroblasts and viral DNA analysis were the same as those of the usual HSV-1 strains. An immunofluorescence study using anti-gC-1 monoclonal antibody and SDS-PAGE analysis of radiolabeled viral glycoproteins showed that these strains are deficient in gC-1. They were virulent for mice and sensitive to acyclovir and bromovinyldeoxyuridine. Furthermore the infectivity of the strains was inactivated by complement though the phenomenon was not observed in the usual HSV-1 strains. This finding suggests that protection from damages by complement is an important function of gC. In keratitis the effects of complement are thought to be minimal because of the scanty blood supply and this may be the reason why these strains were isolated from the cornea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01316673
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Identification of mutation sites of a temperature-sensitive mutant of HCMV DNA polymerase activity (1994)
    Springer
    Archives of virology 137 (1994), S. 263-275 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The human cytomegalovirus (strain Towne) temperature-sensitive mutant ts 256 exhibits a virus specific DNA polymerase-negative phenotype. The position of the mutation of ts 256 was determined by three step marker-rescue assays to be within a 5.1 kbXbaI-BamHI fragment between map unit 0.33 and 0.35 in aHindIII-D fragment located in a long unique region. Nucleotide sequencing showed that the 5.1 kb fragment contained three open reading frames corresponding to those of the genes for UL52, UL53 and UL54 (DNA polymerase gene), respectively, of strain AD169. The functions of UL52 and UL53 are unknown. Comparison of the DNA sequences of the 5.1 kb fragments of the wild-type and ts 256 mutant revealed two base changes within UL53 and UL54, respectively, which result in amino acid substitutions. The mutation in the UL54 gene was located within a distinct conserved region VI common to α-like DNA polymerases, suggesting that this base change would be responsible for DNA negative phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309474
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    Paper (German National Licenses)
    Fulltext
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