ISSN:
1432-2307
Keywords:
CD4+ T cells
;
Primed helper T cells
;
Naive helper T cells
;
Salivary glands
;
Sjogren's syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This study has investigated the presence and distribution of B cells, T cells and T-cell subsets within labial glands of patients with primary Sjogren's syndrome (n=9) and secondary Sjogren's syndrome associated with rheumatoid arthritis (n=8) using a sequential double immunoperoxidase technique and true colour image analysis. The composition of the inflammatory infiltrates was similar in glands from both patient groups. B cells were normally present within large foci with few detected in diffuse infiltrates such that the ratio of T∶B cells in foci (2.4∶1) was significantly lower than in diffuse infiltrates (7.3∶1; P〈0.001). In all infiltrates helper T cells (CD8−, CD3+) predominated over suppressor/cytotoxic cells (CD8+, CD3+; 2.7∶1). Analysis of primed (CD45RA−, CD45RO+) and naive (CD45RA+, CD45RO−) CD8− T cells showed that the ratio of the primed to naive subset was significantly higher in focal (4.2∶1) compared to diffuse (1.5∶1;P〈 0.001) areas of lymphoid infiltration. These results indicate that the focal lymphocytic infiltrates characteristic of Sjogren's syndrome contain B cells associated with a T-cell population consisting predominantly of primed CD8− helper T cells. This latter population may be responsible for upregulating glandular B-cell activity in Sjogren's syndrome.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01626347
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