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  • 1
    Electronic Resource
    Electronic Resource
    Effects of monoamine oxidase inhibition by selegiline on concentrations of noradrenaline and monoamine metabolites in CSF of patients with Alzheimer's disease (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 193-202 
    Details
    ISSN: 1435-1463
    Keywords: Selegiline ; noradrenaline ; monoamine metabolites ; monoamine oxidase ; CSF ; Alzheimer's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A double-blind, cross-over trial with 12 patients with Alzheimer's disease (AD) was carried out primarily to test the suitability of this design in the investigation of the clinical, effects of selegiline (10 mg/day) in AD. Cerebrospinal fluid (CSF) samples for the determination of concentrations of noradrenaline (NA) and several monoamine metabolites were collected at baseline and at the end of both four-week treatment periods (placebo and selegiline). The severity of dementia was assessed using Ferm's and Gottfries-Bråne-Steen (GBS) dementia scales. The concentrations of the dopamine metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC) and the NA metabolites, 3,4-dihydroxyphenylglycol (DHPG), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) decreased significantly during selegiline treatment. There was a clear trend of reduction in concentrations of homovanillic acid (HVA) during selegiline treatment, whereas the concentrations of NA, 5-hydroxyindoleacetic acid (5-HIAA), and tryptophan did not differ significantly. The study design was not suitable for the analysis of the clinical results as there was a significant carry-over effect in both scales. As only the first period data could be used in the analysis, there were no significant differences in the scores of Ferm's or GBS scales, but clear positive trends could be detected in favour of selegiline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02257674
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 287-290 
    Details
    ISSN: 1432-1041
    Keywords: COMT inhibition ; Nitecapone ; haemodynamics ; catecholamines ; exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied resting and exercise haemodynamics and catecholamine disposition after catechol-O-methyl-transferase (COMT) inhibition with nitecapone 100 mg t. d. s. for 7 days in 15 healthy men (aged 21 to 28 y) in a placebo-controlled, cross-over study. Nitecapone did not alter resting or exercise heart rates, blood pressure, or plasma catecholamine concentrations, but it altered the metabolic profile of endogenous catecholamines, as shown by: (1) a fall in the concentrations of the COMT-dependent metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) by 22% (P〉0.01), (2) increases in plasma concentrations of the monoamine oxidase-dependent metabolites 3,4-dihydroxyphenylglycol (DHPG) by up to 90% (P〈0.001) and 3,4-dihydroxyphenylacetic acid (DOPAC) by 67% (P〈0.05), (3) a three-fold increase in the concentration of circulating conjugated adrenaline (P〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00271374
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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