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  • 1990-1994  (2)
  • 1
    Electronic Resource
    Electronic Resource
    The surface membrane antigen phenotype of human blood basophils (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Basophils are effector cells of allergic reactions and express a unique profile of cellular antigens (Ag). Using a combined toluidine-blue/immunofluorescence staining method, we were able to study the cell membrane Ag phenotype of normal human blood basophils with monoclonal antibodies (mAbs) against established and novel CD antigens. According to previous findings, basophils express CD9 (p24), CDlla (LFA-1 alpha-chain), CDllb (C3biR), CDllc (CR4), CD13 (aminopeptidase N), CDwl7 (lactosylceramide), CD18 (beta-chain of β2), CD25 (IL-2R alpha-chain), CD26 (dipeptidylpeptidase), CD31 (PECAM), CD35 (CR1), CD38 (T10), CD43 (leukosialin), CD44 (Pgp-1), CD45 (pan-leukocyte Ag), and CD63 (basophil activation Ag). Various novel CD Ags were detected on basophils, including membrane cofactor protein (MCP) (CD46), the N-linked glycan CD47, decay-accelerating factor (DAF) (CD55), membrane attack complex inhibitory factor (MACIF) (CD59), LFA-3 (CD58), ICAM-2 (CD 102), ICAM-3 (CD50), C5a receptor (CD88), MIC-2/E2 (CD99), and the interleukin-1 (IL-1) R type II (CD121b). These data provide further evidence that basophils express a unique profile of surface membrane receptors for cytokines and immunomodulating compounds, as well as adhesion molecules and surface glycolipids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb00788.x
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  • 2
    Electronic Resource
    Electronic Resource
    Differential expression of cell surface integrins on human mast cells and human basophils (1992)
    Springer
    Annals of hematology 65 (1992), S. 10-16 
    Details
    ISSN: 1432-0584
    Keywords: Basophil leukocytes ; Mast cells ; Adhesion receptors ; Integrins ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Integrins are multifunctional recognition molecules and are expressed on various hematopoietic cells. In the present study expression of integrins on the cell surface of human mast cells and human basophils was investigated by using monoclonal antibodies (mAbs) and indirect immunofluorescence. Human mast cells were obtained from lung (n = 5), uterus (n = 5) and skin (n = 4). Human blood basophils were obtained from normal donors (n = 2). In addition, HMC-1 cells (human mast cell line) and KU-812 cells (a basophil cell line) were analyzed. Primary mast cells were found to react with mAbs directed against the common β chain of β 1 integrins (CD 29), the α chain of VLA-4 (CD49d) and VLA-5 (CD49e), the β chain of β 3 integrins (CD 61), and the α chain of the vitronectin receptor (VNR) (CD 51). Mast cells were not recognized by mAbs to β 2 integrins (CD 18, CD 11 a, CD 11b, CD 11c), the α chain of VLA-2 (CD 49 b), and VLA-6 (CD 49 f). No differences in expression of integrins on human mast cells obtained from different organs were found. HMC-1 cells and primary mast cells expressed an almost identical pattern of integrins. Human basophils and KU-812 cells were found to react with mAbs directed against β 1-integrins (CD 29, CD 49 b, CD 49 d, CD 49 e) and β 2-integrins (CD 18, CD 11 a, CD 11 b, CD 11 c). Together, mast cells and blood basophils express a unique pattern of integrins. These cell surface structures may be involved in the distribution of basophils and tissue mast cells and their accumulation and function in inflammed tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715119
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    Paper (German National Licenses)
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