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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 31 (1992), S. 1625-1637 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 36 (1990), S. 1119-1132 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The synthesis of biochemical pathways satisfying stoichiometric constraints is discussed. Stoichiometric constraints arise primarily from designating compounds as required or allowed reactants, and required or allowed products of the pathways; they also arise from similar restrictions on intermediate metabolites and bioreactions participating in the pathways. An algorithm for the complete and correct solution of the problem is presented; the algorithm satisfies each constraint by recursively transforming a base-set of pathways. The algorithm is applied to the problem of lysine synthesis from glucose and ammonia. In addition to the established synthesis routes, the algorithm constructs several alternative pathways that bypass key enzymes, such as malate dehydrogenase and pyruvate dehydrogenase. Apart from the construction of pathways with desired characteristics, the systematic synthesis of pathways can also uncover fundamental constraints in a particular problem, by demonstrating that no pathways exist to meet certain sets of specifications. In the case of lysine, the algorithm shows that oxaloacetate is a necessary intermediate in all pathways leading to lysine from glucose, and that the yield of lysine over glucose cannot exceed 67% in the absence of enzymatic recovery of carbon dioxide.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 161-183 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article presents a methodology for the continuous detection and definition of process performance improvement opportunities, especially as these pertain to the quality of operations (such as product quality). The problem is first reduced to an essentially pattern recognition formulation, for which an integrated and adaptive methodology combining analogical reasoning and symbolic induction is developed. The resulting classification of past records of data is used to support the construction of a decision support system for the generation/selection of operating suggestions leadin to performance improvements. The overall approach complements the usual set of statistical tools, commonly employed to address quality management problems. The basic methodology is also extended to handle fuzzy class definitions and function learning formulations. Case studies, covering both simulated and real industrial situations, illustrate the concepts and their practical utility.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 39 (1993), S. 57-81 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A Wave-Net is an artificial neural network with one hidden layer of nodes, whose basis functions are drawn from a family of orthonormal wavelets. The good localization characteristics of the basis functions, both in the input and frequency domains, allow hierarchical, multiresolution learning of input-output maps from experimental data. Furthermore, Wave-Nets allow explicit estimation for global and local prediction error-bounds, and thus lend themselves to a rigorous and explicit design of the network. This article presents the mathematical framework for the development of Wave-Nets and discusses the various aspects of their practical implementation. Computational complexity arguments prove that the training and adaptation efficiency of Wave-Nets is at least an order of magnitude better than other networks. In addition, it presents two examples on the application of Wave-Nets; (a) the prediction of a chaotic time-series, representing population dynamics, and (b) the classification of experimental data for process fault diagnosis.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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