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  • 1
    Electronic Resource
    Electronic Resource
    The Intersubunit Region of the Influenza Virus Haemagglutinin is Recognized by Antibodies During Infection (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 40 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influenza virus haemagglutinin has an important role in the infectious cycle of the virus and carries multiple B and T cell epitopes. It is synthesized as a single polypeptide chain but viral infectivity depends on its post-translational enzymatic cleavage. The cleavage site of a trypsin-like enzyme responsible for this modification is found in the most conserved intersubunit region of the molecule. In this study the role of this region in antibody recognition was investigated. Synthetic peptides comprising the intact and cleaved forms of the intersubunit segment were used to examine the specificity of virus- or peptide- induced antibodies. The immune response elicited by viral infection resulted in the appearance of antibodies capable of neutralizing the virus without interfering with its binding to the receptor. A monoclonal antibody (MoAb) of such functional properties was shown to recognize the intact intersubunit region both in the uncleaved haemagglutinin molecule and in a 25-mer synthetic peptide comprising the intact intersubunit region. Specificity and functional studies revealed the conformation dependent recognition of the C-terminal segment of the haemagglutinin 1 subunit by this MoAb. The binding of the antibody was shown to inhibit the trypsin-mediated cleavage of the haemagglutinin molecule and the membrane fusion event. The enzymatic cleavage of the haemagglutinin was demonstrated to abolish antibody recognition of the infective virus suggesting an escape mechanism mediated by the functional destruction of this highly conserved region. The synthetic peptide corresponding to the intact intersubunit region is characterized by an ordered structure and is able to elicit an antibody response in BALB/c mice while its subfragments are nonimmunogenic. Furthermore, this peptide elicited a protective immune response demonstrated by in vivo experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03464.x
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  • 2
    Electronic Resource
    Electronic Resource
    Harmonic maps between complex projective spaces (1990)
    Springer
    Geometriae dedicata 33 (1990), S. 37-50 
    Details
    ISSN: 1572-9168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Using the DoCarmo-Wallach theory, we classify (homogeneous) polynomial harmonic maps of complex projective spaces into spheres and complex projective spaces in terms of finite dimensional moduli spaces. We make use of representation theory of the (special) unitary group to give, for a spherical range, the exact dimension and, for complex projective spaces, a lower bound of the dimension of the moduli spaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00147599
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  • 3
    Electronic Resource
    Electronic Resource
    On finite multiple packings (1990)
    Springer
    Archiv der Mathematik 55 (1990), S. 407-411 
    Details
    ISSN: 1420-8938
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01198482
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  • 4
    Electronic Resource
    Electronic Resource
    Blichfeldt's density bound revisited (1993)
    Springer
    Mathematische Annalen 295 (1993), S. 721-727 
    Details
    ISSN: 1432-1807
    Keywords: 52C17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01444913
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  • 5
    Electronic Resource
    Electronic Resource
    Ketal mediated diels-alder type dimerization of an arylideneacetone (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 425-432 
    Details
    ISSN: 1434-4475
    Keywords: Diels-Alder cycloaddition ; Ketal-enolether equilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Bei der Ketalisierung des Arylidenaceton-Derivates1 erfolgt eine Diels-Alder-Dimerisierung des Ethylenketals2 zu einem 4-Acetyl-3,5-diaryl-cyclohexanon5.
    Notes: Summary During ketalization with ethyleneglycol an arylideneacetone1 dimerized via its ketal2 to give a 4-acetyl-3,5-diarylcyclohexanone ketal5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811860
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  • 6
    Electronic Resource
    Electronic Resource
    A radiopharmaceuticals schedule for imaging in paediatrics (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 127-129 
    Details
    ISSN: 1619-7089
    Keywords: Paediatrics ; Radiopharmaceuticals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is no standard schedule for the amounts of radiopharmaceutical administered to children at present. Various alternative methods are currently in practice, all with some support from the literature. Optimization of the amount of radiopharmaceutical to be administered is discussed in relation to the radiation burden of such an examination. The Paediatric Task Group of the European Association of Nuclear Medicine has investigated the current situation and now suggests a method for standardization of administered amounts of radiopharmaceutical in paediatrics. The fraction of the adult amount of radiopharmaceutical to be administered should be calculated from the child's body weight according to the accompanying table. In small infants, the minimum amount of a radiopharmaceutical is discussed and suggested amounts to be administered are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811439
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  • 7
    Electronic Resource
    Electronic Resource
    Convexly independent sets (1990)
    Springer
    Combinatorica 10 (1990), S. 195-202 
    Details
    ISSN: 1439-6912
    Keywords: 52 A 10 ; 05 A 17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract A family of pairwise disjoint compact convex sets is called convexly independent, if none of its members is contained in the convex hull of the union of the other members of the family. The main result of the paper gives an upper bound for the maximum cardinalityh(k, n) of a family ℱ of mutually disjoint compact convex sets such that any subfamily of at mostk members of ℱ is convexly independent, but no subfamily of sizen is.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02123010
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of the specific activity of the tracer on rat luteinizing hormone radioimmunoassay (1990)
    Springer
    Journal of radioanalytical and nuclear chemistry 144 (1990), S. 79-87 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Rat luteinizing hormone /LH/ was labelled with125I by the Chloramine T method.125I-LH, used as tracer in radioimmunoassay, was separated from the labelling reaction mixture by gel filtration. By using the proper protein/radioiodine ratio in the labelling reaction mixture the specific activity of125I-LH was adjusted to 2.5–20.5 MBq μg−1. The influence of the specific activity on the assay parameters as well as on the tracer stability was investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02162190
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  • 9
    Electronic Resource
    Electronic Resource
    On the formation of125IO3 − ions in the Chloramine-T labeling mixture (1993)
    Springer
    Journal of radioanalytical and nuclear chemistry 176 (1993), S. 169-174 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The formation of125IO3 − ions in the course of labeling proteins with125I by the use of the Chloramine-T method has been investigated. It was demonstrated that one of the components of the labeling reaction mixture is125IO3 −. The identification of radio-iodate ions was performed by the use of paper electrophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02163197
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  • 10
    Electronic Resource
    Electronic Resource
    A new method for the production of a magnetic immunosorbent used in radioimmunoassay and immunoradiometric assay (1994)
    Springer
    Journal of radioanalytical and nuclear chemistry 181 (1994), S. 263-279 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A method has been developed enabling the direct coupling of first or second antibody to finely dispersed magnetite (Fe3O4). The immunosorbent thus produced was applied in various radioimmunoassay systems (T3, T4, TSH, Cortisol) for the separation of bound and free antigens. The elimination of the need for “precoating” the magnetic particles with a polymer has several advantages. One of them lies in the ease of one-step production of the immunosorbent and other is the high antibody/magnetite ratio. The influence of the concentration of the immunosorbent and detergent (TWEEN 20 or TRITON X-100) on the assay parameters (Bo, NSB, etc.) has been systematically investigated and the optimum concentration of the magnetizable particles and detergent has been determined. The reliability of magnetic separation has been validated by comparing it with the conventional PEG separation method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02037633
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