Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 8 (1994), S. 171-176 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The earliest genetic alteration in human astrocytoma progression is mutation of the p53 tumour suppressor gene, while one of the earliest phenotypic changes is the stimulation of neovascularization. Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1094-171
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Climatically induced rapid acidification of a softwater seepage lake (1990)
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 374-376 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The ANC of softwater lakes is determined by four main factors: the geological setting, the hydrological paths of inputs, internal alkalinity generation, and the atmospheric loading rates of mineral acids. Seepage lakes are defined hydrologically by the absence of permanent inlets and outlets of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/347374a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A new highly polymorphic DNA restriction site marker in the 5′ region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhabdomyosarcoma (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 349-350 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have isolated a new marker (cos11-5TH) that detects an MspI restriction fragment length polymorphism in the 5′ region of the human tyrosine hydroxylase gene (TH) on chromosome band 11p15.5. This region of human chromosome 11 contains several important loci for disease phenotypes including Beckwith-Wiedemann syndrome (BWS), Wilms' tumor, and embryonal rhabdomyosarcoma. Thus, identification of new polymorphic markers in this region are important for future gene mapping and linkage analyses. To better define the region of 11p15.5 deleted in embryonal rhabdomyosarcoma, this new marker was used to investigate allelic losses in embryonal rhabdomyosarcoma tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212038
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Relationship between transcript production and virus resistance in transgenic tobacco expressing the potato leafroll virus coat protein gene (1993)
    Springer
    Plant cell reports 13 (1993), S. 54-58 
    Details
    ISSN: 1432-203X
    Keywords: Genetically engineered resistance ; segregation ratios ; potato leafroll luteovirus ; coat protein ; transcript RNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The coat protein (CP) gene of potato leafroll luteovims (PLRV) was inserted into tobacco (Nicotiana tabacum) using disarmed Agrobacterium tumefaciens (LBA4404) containing a binary expression vector. PLRV CP gene transcript was detected in transgenic plants but its abundance differed between transformed lines. CP was not detected in virus-free transgenic plants. The segregation of kanamycin resistance in S1 seedling progenies (obtained by selfing transformed plants) indicated that multiple (up to five) integration events involving vector T-DNA had occurred in most transformants. However, the amount of detectable CP transcript was not related to the neomycin phosphotransferase II gene copy number. Multiplication of PLRV in mature transgenic plants was diminished by up to 6-fold; the greatest diminution was in those transformed lines in which most CP gene transcript was detected. However, S1 progeny seedlings of transgenic plants were no more resistant to infection, following inoculation with viruliferous aphids, than seedlings of non-transformed control plants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232316
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10 (1993)
    Springer
    Human genetics 〈Berlin〉 92 (1993), S. 169-174 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A panel of glial tumors consisting of 11 low grade gliomas, 9 anaplastic gliomas, and 29 glioblastomas were analyzed for loss of heterozygosity by examining at least one locus for each chromosome. The frequency of allele loss was highest among the glioblastomas, suggesting that genetic alterations accumulate during glial tumor development. The most common genetic alteration detected involved allele losses of chromosome 10 loci; these losses were observed in all glioblastomas and in three of the anaplastic gliomas. In order to delineate which chromosome 10 region or regions were deleted in association with glial tumor development, a deletion mapping analysis was performed, and this revealed the partial loss of chromosome 10 in eight glioblastomas and two of the anaplastic gliomas. Among these cases, three distinct regions of chromosome 10 were indicated as being targeted for deletion: one telomeric region on 10p and both telomeric and centromeric locations on 10q. These data suggest the existence of multiple chromosome 10 tumor suppressor gene loci whose inactivation is involved in the malignant progression of glioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219686
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Detection of potato virus Y in potato tubers: a comparison of polymerase chain reaction and enzyme-linked immunosorbent assay (1993)
    Springer
    Potato research 36 (1993), S. 13-20 
    Details
    ISSN: 1871-4528
    Keywords: reverse transcription ; PCR ; immunoassay ; virus detection ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary A method was devised by which specific sequences of potato virus Y (PVY) RNA could be detected in total tuber RNA extracts by reverse transcription into cDNA and amplification by polymerase chain reaction (PCR). This method of PVY detection was tested and compared with the antibody-trapped antigen form of enzyme-linked immunosorbent assay (ATA-ELISA) using monoclonal antibodies. Both PCR and ATA-ELISA could detect PVY reliably in progeny tubers taken from growing plants of cv. Record, or tubers stored for 3 weeks after harvest. The ability to detect PVY decreased substantially after tubers had been stored for 20 weeks at 10°C. ATA-ELISA detected virus in only half the tubers from infected plants. However, PCR detected PVY very inefficiently in infected tubers after 20 weeks storage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02359829
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Isoenzyme variation within the genusCryptosporidium (1993)
    Springer
    Parasitology research 79 (1993), S. 385-388 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Soluble extracts of the oocysts ofCryptosporidium parvum had demonstrable, but low, activities of malate dehydrogenase (MDH, EC. 1.1.1.37), carboxylesterase (ES, EC 3.1.1.1) and lactate dehydrogenase (LDH, EC. 1.1.1.27) following thin-layer starch-gel electrophoresis. Much higher activities of glucose phosphate isomerase (GPI, EC. 5.3.1.9) and phosphoglucomutase (PGM, EC. 2.7.5.1) were found, and zymograms of these two enzymes were used to characterise isolates ofC. parvum from human, bovine, ovine and cervine sources,C. muris from the brown rat andC. baileyi from young turkeys. PGM and GPI zymograms clearly distinguished betweenC. parvum, C. muris andC. baileyi. The five isolates ofC. parvum showed the same electrophoretic mobility for GPI, whereas the PGM mobilitiy of the single human isolate ofC. parvum examined was clearly different from that of the other isolates. This is the first report of the use of isoenzymes to distinguish between species and isolates ofCryptosporidium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931827
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Genetics of the malignant progression of astrocytoma (1991)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 46 (1991), S. 3-8 
    Details
    ISSN: 0730-2312
    Keywords: glioma ; cytogenetics ; molecular genetics ; tumor progression ; glioblastoma staging ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The tendency of human cancers to progress towards a more malignant state over time is a well described biological phenomenon. Recent investigations elucidating the genetic nature of malignancy and the possible mechanisms responsible for this evolution have suggested that a sequential pathway may exist whereby a cell population accumulates a nested set of genetic aberrations which endow it with the ability to overwhelm other populations and dominate the tumor. Human astrocytomas are a dramatic case in point, where specific genetic events of amplification and deletion are seemingly related to the stages of malignancy. The identification of these aberrations represents the first stage in the dissection of the temporal process of this cancer. Its augmentation with functional analyses will likely allow a fuller genetic description of in vivo transformation.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240460103
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...