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Resolution of derivatized acids and amines on JTB-X: A new urea bonded chiral stationary phase (1990)

Kakodkar, Sunil V. ; Zief, Morris

New York, NY [u.a.] : Wiley-Blackwell

Chirality 2 (1990), S. 124-127

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ISSN: 0899-0042

Keywords: anti-inflammatory drugs ; chiral drugs ; derivatized amino acids ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A new urea-bonded chiral stationary phase has been developed in our laboratory. This bonded phase has been shown to resolve N-terminal substituted amino acids and the carboxyl derivatized anti-inflammatory drugs. Typical α-value for dinitrobenzoyl phenylglycine was 1.7. Values for derivatized ibuprofen, naproxen, and fenoprofen were 2, 1.84, and 1.6, respectively. Further application of these studies to biologically active compounds such as peptides and drugs is in progress.

Additional Material: 2 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/chir.530020210

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