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  • 1
    Electronic Resource
    Electronic Resource
    The effect of intravenous L-tryptophan on prolactin and growth hormone and mood in healthy subjects (1982)
    Springer
    Psychopharmacology 77 (1982), S. 217-222 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Tryptophan ; Prolactin ; Growth hormone ; Mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to assess the effects of increased central nervous system serotonergic function in humans on prolactin (PRL), growth hormone (GH) and mood, intravenous L-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more high, mellow, and drowsy following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and GH secretion, as well as in mood regulation. The intravenous TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00464569
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of IV l-tryptophan on prolactin, growth hormone, and mood in healthy subjects (1982)
    Springer
    Psychopharmacology 78 (1982), S. 38-43 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Tryptophan ; Prolactin ; Growth hormone ; Mood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to assess the effects of increased CNS serotonergic function in humans on prolactin (PRL), growth hormone (GH), and mood, IV l-tryptophan (TRP) was administered to ten healthy subjects. The TRP infusion induced robust increases in PRL in all ten subjects. A significant increase in GH concentration was also observed, although the response was more variable. The subjects reported feeling significantly more ‘high’, ‘mellow’, and ‘drowsy’ following the TRP infusion in comparison to placebo. These findings indicate an important role for serotonin in PRL and GH secretion, as well as in mood regulation. The IV TRP challenge may be of use in the study of serotonergic function in a variety of neurologic and psychiatric diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470585
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Immunocytochemical and ultrastructural correlates of the pineal inhibition of prolactin cell activity in blind-anosmic female rats (1982)
    Springer
    Cell & tissue research 227 (1982), S. 343-350 
    Details
    ISSN: 1432-0878
    Keywords: Pineal gland ; Prolactin ; Mammotroph ; Blind-anosmic ; Pituitary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of the pineal gland on the light microscopic-immunocytochemical and ultrastructural appearance of pituitary mammotrophs were studied in female rats eight weeks after prepubertal blinding and olfactory bulbectomy. Blinding and anosmia resulted in a marked decrease in the size of the pars distalis concomitant with a reduction in the apparent number and size of PRL cells as compared with intact animals. Ultrastructurally, these cells appeared much less active than those of intact rats. The small and angular-shaped mammotrophs of blind-anosmic rats characteristically exhibited scant arrays of rough endoplasmic reticulum, small Golgi complexes with few immature secretory granules, few mature secretory granules and rare exocytosis patterns. Pinealectomy tended to reverse the effects of blinding and anosmia on pars distalis size and PRL cell size, apparent number and ultrastructure. In fact, the mammotrophs of blind-anosmic-pinealectomized rats were quite similar in ultrastructural appearance to those of intact rats. From these data we conclude that the pineal causes mammotroph hypotrophy and hypoplasia in blind-anosmic female rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210890
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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