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Insulin degradation. XXVIII. Immunocytochemical localization of glutathione-insulin transhydrogenase in the pancreas, kidney and liver of normal and streptozotocin-diabetic rats and of lean and obese (ob/ob) mice (1981)

Taylor, C. A. ; Varandani, P. T.

Springer

Diabetologia 21 (1981), S. 464-469

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ISSN: 1432-0428

Keywords: Immunocytochemistry ; glutathione-insulin transhydrogenase ; thioliprotein-disulphide oxidoreductase ; streptozotocin-diabetic rats ; obese (ob/ob) mice ; pancreatic acini ; islets of Langerhans ; kidney tubules ; liver

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Glutathione-insulin transhydrogenase catalyzes the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats. Localization was achieved by an antibody to glutathione-insulin transhydrogenase using a peroxidase-antiperoxidase technique. In comparison with tissues from control animals, positive immunostaining for glutathione-insulin transhydrogenase was increased in the obese mouse but reduced in the diabetic rat. Different tissues showed considerable variation in the amount of glutathioneinsulin transhydrogenase which could be detected. In the pancreatic islets there was little or no evidence for the presence of the enzyme in peripheral cells. In the kidney, immunocytochemical staining was found only in the proximal tubules. In the liver there was a generalised distribution of the enzyme, but the greatest concentration was in the periportal region. These observations parallel the biochemical data relating to glutathione-insulin transhydrogenase, indicating that different amounts of insulin degrading activity exist in different regions of tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00257787

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Associative organotin polymers. I. Symmetric trialkyltin fluorides: Synthesis and properties (1989)

Dandge, D. K. ; Taylor, C. ; Heller, J. P.

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part A: Polymer Chemistry 27 (1989), S. 1053-1063

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ISSN: 0887-624X

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Four novel symmetric tri-n-alkyltin fluorides were prepared. In this homologous series, melting point decreases with increase in the carbon chain length while an x-ray diffraction study shows an increase in amorphousness. 1H-NMR spectra in cyclohexane, a nonpolar solvent in which these compounds form long polymeric chain, show a peak broadening effect due to high solution viscosity at very low solute concentration. Contrary to this, the spectra in CDCl3, a polar solvent in which these compounds are monomeric, show well resolved and narrow peaks. IR frequencies for Sn—C vibrations have been assigned.

Additional Material: 5 Ill.