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  • 1985-1989  (3)
  • 1980-1984  (2)
  • Analytical Chemistry and Spectroscopy  (4)
  • Carrier diagnosis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Italian experience regarding the prevention of Duchenne and Becker muscular dystrophies (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 412-415 
    Details
    ISSN: 1432-1076
    Keywords: Duchenne muscular dystrophy, Becker muscular dystrophy ; Carrier diagnosis ; Prenatal diagnosis ; X-linked muscular dystrophies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The indirect approach to carrier detection and prenatal diagnosis of Duchenne and Becker muscular dystrophies based on the study of DNA polymorphisms closely linked to this gene has been followed by five Italian laboratories in the study of 106 pedigrees. Out of 354 women studied up to 1 May 1987, 147 were identified as carriers because of pedigree information and/or of increased creatine phosphokinase (CPK) values. Of the remaining 207, 184 could be assigned to three arbitrarily defined risk categories (low, intermediate and high) using linkage analysis. This disaggregation of women at risk is clearly more useful than that defined before DNA analysis, in which the same 184 women could be assigned only to the low or intermediate risk categories. Prenatal diagnosis was theoretically possible in 90% of carrier women, and was actually performed in 14 pregnancies, which led to the identification of four affected male foetuses, one also having Down syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496422
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-onesFor Part IV, see Ref. 5. (1981)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 15 (1981), S. 394-398 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The conformational analysis of biologically active lofendazam (7-chloro-5-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one) is carried out by means of lanthanide shift reagent assisted 1H NMR spectroscopy: the lanthanide induced shift computer simulation suggests that in deuteriochloroform the heterocyclic ring of lofendazam assumes a cycloheptene-like chair conformation, where 1-N moves away from trigonal stereochemistry to a very flattened pyramidal structure. At room temperature the conformational equilibrium is markedly shifted (85%) towards the conformer showing pseudoaxial H-1 and 5-Ph. The remarkable influence of steric requirements in controlling conformation, and the importance of 3- and/or 4-methyl groups in hindering the ring inversion at room temperature, have been verified by conformational analysis of suitable analogous 1,3,4,5-tetraydro-2H-1,5-benzodiazepin-2-ones.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270150414
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance of psychotherapeutic agents. IVFor part III see Ref. 1. - conformational analysis of 2,3-dihydro-1H-1,4-benzodiazepines (1981)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 15 (1981), S. 33-36 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The lanthanide shift reagent (LSR)/1H NMR study of some 7-chloro-5-phenyl-2,3-dihydro-1 H-1, 4-benzodiazepines shows that these compounds exist in CDCI3 solution as two pseudo-boat conformers, rapidly interconverting at room temperature. Computer simulated lanthanide induced shifts (LIS) are consistent with LSR complexation by the imine nitrogen atom. The lanthanide shifts the conformational equilibrium towards conformer (a), with a pseudoequatorial 1-substituent: this effect may be the result of the greater basicity of 4-N when the 1-N lone pair is pseudoaxially directed, thus permitting an extended electron delocalization from 1- to 4-N through the fused benzene ring. The detection of H-9/1-Me through space spin-spin coupling in medazepam (7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine) supports the observed higher availability of conformer (a) to LSR. A LIS computer calculation to predict the population ratio results in reasonable agreement with the conformational changes based on the response of 3J(HH) to lanthanide addition. The electronic and steric effects which determine the greater stability of conformer (a) may be effective in the drug-receptor interaction.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270150109
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of the stereochemistry of isoxazolidinium salts by nuclear Overhauser effect difference spectroscopy (1988)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 26 (1988), S. 974-979 
    Details
    ISSN: 0749-1581
    Keywords: 1H NMR ; NOEDS measurements ; Isoxazolidinium salts ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The configurations of some isoxazolidinium salts have been determined by nuclear Overhauser effect difference spectroscopy (NOEDS). The stereochemical findings give a good explanation of the different reactivities experienced in the five-membered ring-opening process as a function of the steric requirement of the system.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260261108
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  • 5
    Electronic Resource
    Electronic Resource
    13C NMR study of tetrahydrothiazolo-[3,2-d][1,4]benzodiazepin-3[2H]-ones (1989)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 27 (1989), S. 702-705 
    Details
    ISSN: 0749-1581
    Keywords: 13C NMR ; Tetra-hydrothiazolo [3,2-d] [1,4] benzodiazepin -3(2H)-ones ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The complete assignments of the 13C NMR resonances for eight tetra-hydrothiazolo [3,2-d] [1,4] benzodiazepin -3(2H)-ones are reported. The data obtained account for a conformational rigidity of the heptatomic ring as a consequence of the annelation of the thiazolidinone nucleus.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260270720
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    Paper (German National Licenses)
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