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The pathogenesis of abnormal cytoarchitecture in the cerebral cortex and hippocampus of the mouse treated transplacentally with cytosine arabinoside (1982)

Shimada, M. ; Abe, Y. ; Yamano, T. ; [et al.]

Springer

Acta neuropathologica 58 (1982), S. 159-167

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ISSN: 1432-0533

Keywords: Cytosine arabinoside ; Mice ; Microcephaly ; Cerebral cortex ; Hippocampus ; Abnormal cytoarchitecture

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Pregnant mice were treated with cytosine arabinoside on days 13.5 and 14.5 of pregnancy. Brains of the offspring were studied histologically. The matrix layer of the embryonic brains was extensively destroyed 12h after the injection of cytosine arabinoside, but regenerated partially on day 17 of gestation. In the cerebral cortex of 1-, 3-, and 5-day-old treated mice, abnormal clusters of young neurons were found on the surface of the developing cerebral cortex. Some clusters still had a supply of immature neurons from the remnants of the regenerated matrix layer. After 20 days, the clusters became gradually indistinct, although some vestigial groups of neurons were observed even after 120 days. In the hippocampus of young mice, the pyramidal cells decreased in number and were disarranged. Heterotopic pyramidal cell masses were found in the stratum radiatum and in the molecular layer of the dentate gyrus. Apical dendrites of pyramidal cells exhibited abnormal arborization. It was demonstrated by3H-thymidine autoradiography that young neurons in the abnormal clusters in the cerebral cortex were those produced in the matrix layer regenerated after the destructive change by cytosine arabinoside.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00690796

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Detection-threshold of 50-Hz electric fields by human subjects (1989)

Kato, M. ; Ohta, S. ; Shimizu, K. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 10 (1989), S. 319-327

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ISSN: 0197-8462

Keywords: hairy and hairless skin ; relative permittivity of hair ; AC electric field ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: The threshold intensity for detection of an AC electric field was studied in human subjects at several different temperatures and humidities. The dorsum and palm of the hand were exposed to fields, representing hairy and hairless skin, in order to clarify whether hair movement is critical for field detection. Experiments were carried out on human subjects (seven men and four women) during hot humid weather of July-August and dry cool air of October-November. Threshold values obtained in the summer were 30-65 kV/m for the hairy skin on the dorsum of the hand, while for the hairless skin on the palm the threshold was 〉 115 kV/m (highest field available due to limitations of the power supply). During the fall, the threshold was much higher than during the summer. We sought possible reasons for the difference and found that humidity was the main factor. Relative permittivity of woman's hair was then estimated by measuring capacitance of the hairs under dry (35% RH) and wet (85% RH) conditions at 20 °C. The values of relative permittivity obtained under these two conditions differed by several times the average. The differences in detection thresholds may be attributable to the different relative permittivities of the hairs under dry and wet conditions.

Additional Material: 3 Ill.