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  • 1
    Digitale Medien
    Digitale Medien
    The effect of 1α, 25-dihydroxycholecalciferol on iron metabolism (1985)
    Springer
    Annals of hematology 51 (1985), S. 103-108 
    Details
    ISSN: 1432-0584
    Schlagwort(e): 1α, 25-dihydroxycholecalciferol ; iron ; Calcium ; Intestinal absorption ; Ferritin ; Iron overload
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Chronic administration of hypercalcemic doses of 1α, 25-dihydroxycholecalciferol to intact, vitamin-D repleted rats for 4 weeks, enhanced net inestinal absorption of iron and liver iron stores. Daily net iron and calcium absorptions were found to be significantly correlated in both control and treated rats. In duodenal loop experiments, pretreatment with 1α, 25-dihydroxycholecalciferol reversed the adverse effect of high Ca/Fe ratio on iron absorption. The increased intestinal absorption of iron did not result in a change of serum iron levels nor of total iron binding capacity due to the enhanced incorporation of absorbed iron into liver ferritin. The curve of uptake of 59Fe into circulating red cells of treated rats suggested retarded release of the isotope from stores. The hypothesis is advanced that the systemic metabolic defect (tissue hypoxia, raised erythropoietin levels) produced by 1α, 25-dihydroxycholecalciferol is responsible for the disruption of the physiological coordination between iron stores and intestinal absorption.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320118
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Respiratory alkalosis and reduced plasmatic concentration of ionized calcium in rats treated with 1,25 dihydroxycholecalciferol (1984)
    Springer
    Calcified tissue international 36 (1984), S. 604-607 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Respiratory alkalosis ; Ionized calcium ; 1,25 Dihydroxycholecalciferol ; Parathyroid hormone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The daily administration of supraphysiological doses of 1,25 dihydroxycholecalciferol (0.1–2.5 µg/d/100 g body weight) to rats, produced respiratory alkalosis. With the doses of 0.1–0.2 µg/d/100 g and feeding a diet with 0.7% of calcium, calcemias did not exceed 2.75 mM, and significantly reduced plasma ionized calcium levels were measured. The latter phenomenon was found associated with increased urinary excretion of cAMP, soft tissue calcium content, and polyuria with hypostenuria, all known effects of parathyroid hormone. These effects were absent in thyroparathyroidectomized rats treated in the same fashion. Present results suggest that the stimulus of low levels of plasma ionized calcium overcomes the probably inhibitory effect of the steroid on parathyroid hormone secretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02405374
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  • 3
    Digitale Medien
    Digitale Medien
    Effect of 1,25-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol glycoside on 2,3-diphosphoglycerate levels of the rat erythrocyte (1980)
    Springer
    Pflügers Archiv 389 (1980), S. 81-83 
    Details
    ISSN: 1432-2013
    Schlagwort(e): erythrocyte ; 1,25-dihydroxycholecalciferol ; 2,3-diphosphoglycerate phosphorus
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The erythrocytes of rats treated with 1,25-dihydroxycholecalciferol or 1,25-dihydroxycholecalciferol glycoside showed decreased levels of 2,3-diphosphoglycerate. The same result has been obtained in vitro, indicating a direct effect of the sterol on the red cell. The glycoside is less active than the free sterol in vivo and more active in vitro. The decreased levels of diphosphoglycerate induced tissue hypoxia as shown by a higher plasma lactate/pyruvate ratio and a three fold increase in plasma erythropoietin concentration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00587932
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