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  • 1985-1989  (26)
  • 1980-1984  (23)
  • 1
    Electronic Resource
    Electronic Resource
    Total syntheses of derivatives of protoporphyrin IX regioselectively labeled with carbon-13 in the methyls (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 4667-4676 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00374a031
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  • 2
    Electronic Resource
    Electronic Resource
    A proposed kinetic method for improving the optical purity of synthetic peptides (1986)
    s.l. : American Chemical Society
    The @journal of organic chemistry 51 (1986), S. 5419-5421 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00376a071
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  • 3
    Electronic Resource
    Electronic Resource
    Competition of a free rotor and a rigid double bond in a di-.pi.-methane rearrangement. Photolysis of a 2-methylenebicyclo[2.2.2]octadiene (1980)
    s.l. : American Chemical Society
    The @journal of organic chemistry 45 (1980), S. 958-960 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01294a008
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  • 4
    Electronic Resource
    Electronic Resource
    Multiple [35S]t-Butylbicyclophosphorothionate Binding Sites in Rat and Chicken Cerebral Hemispheres (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Specific binding of [35S]t-butylbicyclophosphorothionate (TBPS) to membranes from cerebral hemispheres of adult rat and chicken was determined over a range of radioligand concentrations from 0.25 to 500 nM. Scatchard plots of these data were curvilinear and non-linear regression analysis indicated binding to two sites that differ in affinity. For rat cerebrum, KD(1)= 1.15 nM, Bmax(1) 0.085 pmol/mg; KD(2)= 232 nM, Bmax(2)= 16.9 pmol/mg. For chicken cerebrum, KD(1)= 1.39 nM, Bmax(1)= 0.111 pmol/mg; KD(2)= 166 nM, Bmax(2)= 17.6 pmol/mg. This multiplicity of [35S]TBPS binding was further confirmed when unlabeled TBPS or picrotoxinin displaced radioligand. The displacement curves were biphasic and yielded Hill coefficients from 0.65 to 0.70. These displacement curves were also resolved into two components with distinct IC50 values for unlabeled TBPS (rat, 1.55 and 271 nM; chicken, 2.40 and 224 nM). The IC50 values were similar to the dissociation constants obtained from equilibrium binding measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05560.x
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  • 5
    Electronic Resource
    Electronic Resource
    Interaction of t-Butylbicyclophosphorothionate with γ-Aminobutyric Acid-Gated Chloride Channels in Cultured Cerebral Neurons (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 46 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The role of t-butylbicyclophosphorothionate (TBPS) as an antagonist of γ-aminobutyric acid (GABA) was studied with primary cultures of neurons from the chick embryo cerebrum. The addition of GABA stimulated the uptake of 36Cl− by neurons and the dose dependence of this effect followed hyperbolic kinetics with a K0.5= 1.3 μM for GABA. TBPS proved to be a potent inhibitor of GABA-dependent Cl− uptake (IC50= 0.30 μM). Analysis of the kinetics of this process revealed that TBPS is a noncompetitive inhibitor (Ki= 0.15 μM) with respect to GABA. Scatchard analysis of direct binding of [35S]TBPS to membranes isolated from neuronal cultures gave curvilinear plots. These could be resolved by nonlinear regression methods into two components with KD values of 3.1 nM and 270 nM. The TBPS binding constant for this lower affinity site agreed well with the IC50 and Ki values for inhibition of Cl− flux, suggesting that this site is physiologically relevant to GABA antagonism. GABA was a noncompetitive displacer of [35S]TBPS binding to the lower affinity site. The Ki value for this displacement by GABA (1.7 μM) was comparable to the value for GABA enhancement of Cl− flux. The binding of [35S]TBPS to its low-affinity site on neuronal membranes was ninefold higher in the presence of Cl− than with gluconate, an impermeant anion. The rank order for anion stimulation of [35S]TBPS binding was Br−≧ SCN− 〉 Cl−≧ NO−3 〉 I− 〉 F− 〉 gluconate. The EC50 value for Cl− enhancement of [35S]TBPS binding (160 mM) agreed well with the Km for Cl− influx via GABA-gated channels (140 mM). These results indicate that TBPS acts as a GABA antagonist via direct blockade of neuronal Cl− channels. A minimum density of 6.5 × 104 chloride channels per neuron was obtained from TBPS binding at saturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb01774.x
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  • 6
    Electronic Resource
    Electronic Resource
    Immunoassay Comparison of Haplosporidan Spores from Teredo navalis and Haplosporidium nelsoni Spores from Crassostrea virginica (1989)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 36 (1989), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Spores of a haplosporidan infecting Teredo navalis Linnaeus have been described as morphologically indistinguishable from spores of Haplosporidium nelsoni. To test the hypothesis that these organisms are conspecific, a colloidal gold immunoassay was used to compare antigenic characteristics of the spores from both hosts. Rabbit antibody to formalin-fixed spores from T. navalis was tested against paraffin sections of Crassostrea virginica infected with spores of H. nelsoni and against paraffin sections of infected 7″. navalis. Application of primary antibody was followed by addition of affinity purified goat anti-rabbit IgG coaled on 5-nm colloidal gold particles. The reaction was enhanced by precipitation of metallic silver; a positive reaction appeared as a dark brown to black signal at the site of each antigen-antibody complex. Haplosporidium nelsoni spores did not react when assayed with the antibody made to spores from T. navalis. Spores from infected T. navalis tissue reacted positively with rabbit antibody. This result indicates that the spores from the 2 hosts are antigenicaliy distinct and suggests that they are different species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1989.tb05365.x
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  • 7
    Electronic Resource
    Electronic Resource
    The Life Cycle of Trypanoplasma bullocki (Zoomastigophorea: Kinetoplastida) (1982)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 29 (1982), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The leech Calliobdella vivida (Verrill) is the vector of Trypanoplasma bullocki. At 10°C, infective-stage flagellates were first present in the leech's proboscis sheath five days after feeding. At 5°C, infective-stage flagellates were not present in the leech's proboscis sheath until 10 days after feeding, but at 20°C, flagellates were located there as early as 24 h after feeding. Infected leeches retained flagellates through three subsequent feeds on uninfected fish. When flagellates were first observed in hogchoker, Trinectes maculatus (Bloch & Schneider), they were much larger than infective stages from the leech. Average flagellate length then decreased during early acute phase, but gradually increased thereafter. Peak parasitemia was greater in a hogchoker inoculated by only one leech but held at colder temperature than in a hogchoker inoculated by 45 leeches, suggesting that temperature may be more important than inoculum in determining peak parasitemia. Cell division in the fish host is described. SEM studies of fish blood flagellates revealed a pre-oral ridge and a cytostome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1982.tb02882.x
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  • 8
    Electronic Resource
    Electronic Resource
    Sampling and determination of gas-phase hydrogen peroxide following removal of ozone by gas-phase reaction with nitric oxide (1986)
    s.l. : American Chemical Society
    Analytical chemistry 58 (1986), S. 1857-1865 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00121a056
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  • 9
    Electronic Resource
    Electronic Resource
    Magnetic properties of amorphous ferromagnets (invited) (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 64 (1988), S. 5770-5775 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Some magnetic properties of amorphous ferromagnets are well described within the random-anisotropy real-space model. This model assumes that the neighboring spins are ferromagnetically coupled with each other, and that there is a local magnetic anisotropy whose axes are correlated over a small length Ra due to short-range structural order. The system is characterized by a small parameter λ∼R2aK/A which depends on temperature and on the concentration of magnetic atoms via the local anisotropy K and exchange constant A. In zero magnetic field the local magnetization smoothly rotates over the solid with a characteristic length Rf =Ra/λ2. The zero-field susceptibility is very sensitive to the exchange, the anisotropy, and the amorphous structure: χ∝A3K−4R−6a. The magnetization law in approaching saturation (M→M0) is universal (M0−M)∝1/(H)1/2 for H〈2A/M0R2a. These and other predictions of the model seem to be in a good agreement with many recent experimental results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342227
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  • 10
    Electronic Resource
    Electronic Resource
    Calcium Transport by Primary Cultured Neuronal and Glial Cells from Chick Embryo Brain (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 36 (1981), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The uptake of calcium was examined in primary cultures of pure neurons and of glial cells from dissociated hemispheres of chick embryo brain. Neuronal cultures took up calcium at a rate of 2.0 nmol per min per mg cell protein at medium concentrations of 1.2 mM-Ca2+ and 5.4 mM-K+. The rate of calcium entry into neurons was increased 2.7-fold by elevating medium potassium to 60 MM. The effect of high external potassium was to increase the Vmax value for calcium transport from 5.5 to 13 nmol per min per mg; the Michaelis constant for calcium, 1.2 mM, was unchanged. The potassium-dependent component of calcium entry into the neuronal cultures was eliminated by addition of 0.1 mM-D-600 (a verapamil derivative) or by 1 mM-CoCl2, but 0.5 μM-tet-rodotoxin had no significant effect. When choline replaced potassium in uptake medium no change in calcium transport was detected in neurons, nor was the entry of calcium increased when choline replaced sodium. Glial cultures took up calcium at 20% of the basal rate for neuronal cultures on a weight-of-protein basis. Uptake was not increased by potassium; during depolarization by potassium the calcium transport activity of glia was less than 10% that of neurons. It was concluded that cultured neurons contain a depolarization-sensitive, calcium-specific channel. A similar calcium transport activity was not detected in cultured glial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1981.tb02380.x
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