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Electronic Resource

Human Learning and Memory (1987)

Johnson, M K ; Hasher, L

Palo Alto, Calif. : Annual Reviews

Annual Review of Psychology 38 (1987), S. 631-668

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ISSN: 0066-4308

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Psychology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.ps.38.020187.003215

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Repeated small doses of a neurotoxic organophosphate (1980)

Lotti, Marcello ; Johnson, M. K.

Springer

Archives of toxicology 45 (1980), S. 263-271

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ISSN: 1432-0738

Keywords: Organophosphate neuropathy ; Organophosphate ; Chronic dosing ; Neurotoxic esterase

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful histological signs of neuropathy were detected. Neuropathy could be precipitated by depressing the level to 〈 20% either with a single high dose (50 mg/kg), or by an increase of the repeated dose level to 5 mg/kg/day. There was no correlation between inhibition of NTE in the nervous tissue and the “NTE-like” activity in lymphocytes. “NTE-like” activity in spleen was consistently inhibited but to a lesser extent than that in the brain or spinal cord. Brain AChE and BuChE were not affected.