Electronic Resource
Springer
European journal of pediatrics
146 (1987), S. 598-600
ISSN:
1432-1076
Keywords:
Haemoglobin switch
;
Hb A2
;
Maturity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract From 70 infants born after gestation periods of 28–41 weeks Hb F and Hb A2 were determined in the cord blood; Hb A was calculated from the two values. Hb F decreased with maturity, Hb A and Hb A2 increased. The percentage of Hb A2 calculated from the sum of Hb A+Hb A2 (non-fetal Hb) increased from 0.57% to 0.83% with maturity. These values are much lower than those in adult controls (1.83%). The results show that during development the synthesis of the δ-globin chains lags behind that of the β-globin chains. This is remarkable considering the location of the δ-globin gene within the β-globin like gene cluster.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02467363
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