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  • 1985-1989
  • 1975-1979  (2)
  • 1935-1939
  • Cerebral blood flow  (1)
  • DNA levels  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of vitamin A acid on the growth of keratinocytes in culture (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 75-81 
    Details
    ISSN: 1432-069X
    Keywords: Keratinocyte cell culture ; Retinoic acid ; Thymidine incorporation ; DNA levels ; Keratinocytenkultur ; Vitamin A-Säure ; Thymidin-Einbau ; DNS-Konzentrationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß von Vitamin A-Säure auf Gewebekulturen von Keratinocyten gewonnen von Meerschweinchen-Ohren wurde untersucht. Vitamin A-Säure sowie die Vorbehandlung der Plastik-Petri-Schalen mit einer Kollagen-Suspension erleichterte die Zelladhäsion und das Wachstum. Vitamin A-Säure versursachte eine DNS-Synthese-Welle, die durch den Einbau von 3H-Thymidin und die Bestimmung der cellulären DNS nachgewiesen werden konnte. Diese DNS-Synthese erfolgte 24–45 h nachdem die Keratinocyten angesetzt wurden. Während dieser Zeitspanne resultierte die Vorbehandlung mit Vitamin A-Säure in einer zehnfachen Erhöhung des Einbaus von 3H-Thymidin und zeigte ein komplexes Muster von Gipfeln und Schultern, welche die synchrone S-Phase der Keratinocyten darstellen könnte.
    Notes: Summary The effect of vitamin A acid on the culture of guinea pig ear keratinocytes was investigated. Use of this agent and treatment of the plastic dishes with collagen solution facilitated attachment and growth. Vitamin A acid elicited a wave of DNA synthesis which was studied by incoporation of tritiated thymidine and quantitation of cellular DNA, particularly during the period 24–45 h after plating. During this period, thymidine incorporation into DNA was increased ten-fold by vitamin A acid and showed a complex pattern of peaks and shoulders which may represent the S phase of synchronous keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446856
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of increasing arterial pressure on cerebral blood flow in the baboon: Influence of the sympathetic nervous system (1979)
    Springer
    Pflügers Archiv 378 (1979), S. 189-195 
    Details
    ISSN: 1432-2013
    Keywords: Cerebral blood flow ; Sympathetic ; Hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of stimulation of the cervical sympathetic chain on the response of cerebral blood flow to hypertension induced by the intravenous infusion of angiotensin was studied in anaesthetised baboons. Cerebral blood flow was measured by the intracarotid133Xenon injection technique. Possible lesions of the blood-brain barrier were studied by injecting Evans blue towards the end of the experiment and ischaemic brain damage was assessed following perfusion fixation. In a control group of five baboons blood flow increased by 53±9% (mean ±S.E.) from the base line values in the arterial pressure range 130–159 mm Hg. In four baboons subjected to unilateral sympathetic stimulation flow increased by 16±4% in the same pressure range. In three babbons subjected to bilateral sympathetic stimulation there were not significant increases in flow until the arterial pressure had increased above 159 mm Hg. Disruption of the blood-brain barrier in the parietooccipital regions was only seen in the control animals but not in the stimulated baboons. Ischaemic brain damage was not observed with the exception of one small lesion in a single stimulated baboon. These findings provide strong support for the observations of Bill and Linder (1976) that activation of the cervical sympathetic can modify the level at which breakthrough of cerebral blood flow occurs in association with systemic hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592735
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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