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  • 1
    ISSN: 1573-1561
    Keywords: Black-tailed deer ; “deer lactone” ; discrimination ; enantiomers ; (Z)-4-hydroxy-6-dodecenoic acid lactone ; Odocoileus hemionus columbianus ; lactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Urine of the black-tailed deer is the source of the “deer lactone,” which is deposited on the tarsal gland tufts by “rub-urination.” The enantiomer composition of the lactone from the urine of the female is 89(R)-(−)/11(S)-(+). Responses by deer were strongest toward the synthetic racemic lactone in the social test and toward the natural lactone in the choice test. In both tests, the (−)- lactone released slightly stronger responses than its enantiomer.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of chemical ecology 1 (1975), S. 125-131 
    ISSN: 1573-1561
    Keywords: deer ; mammals ; odor preference ; odor specificity ; olfactory discrimination ; pheromone ; sexual isolation ; social odor ; tarsal scent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two subspecies of deer, black-tailed deer (Odocoileus hemionus columbianus) and Rocky Mountain mule deer (O. h. hemionus) were exposed to the tarsal scents of both subspecies in a social setting. The scent was sprayed on one individual in a group. The responses, consisting of sniffing, licking, and following, were stronger to each subspecies' own tarsal scent. This discrimination may be important for sexual isolation in areas where the ranges of the two species overlap.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of chemical ecology 2 (1976), S. 389-398 
    ISSN: 1573-1561
    Keywords: Black-tailed deer ; geometric isomers ; (E) and (Z)-4-hydroxy-6-dodecenoic acid lactone ; mammals ; Odocoileus hemionus columbianus ; olfactory discrimination ; pheromones ; stereoisomers ; tarsal scent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Black-tailed deer (Odocoileus hemionus columbianus) discriminate between the geometric isomers of a lactone used as a pheromone by the species. They react strongly to (Z)-4-hydroxy-6-dodeceonic acid lactone, which occurs in their tarsal scent, but the response to theE isomer did not differ from the response to the solvent. The isomers were applied to one member of a group of freely interacting deer, and the sniffing, licking, and following responses were recorded. The synthesis of the geometric isomers of the lactone is described.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 399-401 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To characterise the active components, micromolecular FDPs were separated on Sephadex G-25. All preparations revealed four peaks (1, 2, 3 and 4), the first appearing with the void volume (Fig. 2). Peaks were reduced to the initial volume of the sample and tested in the lymphocyte culture. A marked ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 152 (1930), S. 91-110 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Ausgehend von der erregbarkeitssteigernden Wirkung des Bleiazetats, die Wolpe an der Muskulatur des Meerschweinchenuterus gegenüber Bariumchlorid, Adrenalin und Papaverin feststellte, wurden an der Blutegelmuskulatur zahlreiche Metallsalze verschiedenster Gruppen hinsichtlich einer Erregbarkeitssteigerung gegenüber der erregenden Wirkung von Bariumchlorid geprüft. Wie am Meerschweinchenuterus verhielt sich Bleiazetat und gleich diesem Bleinitrat auch am Blutegelpräparat. Von den geprüften Metallverbindungen zeigten mehrere die erregbarkeitssteigernde Eigenschaft der Bleisalze. Es sind dies Platinchlorid, Bleiazetat und -nitrat, basisches Wismutnitrat in der angegebenen Lösung mit kräftiger Wirkungsverstärkung; Cadmiumnitrat, Thalliumazetat und -nitrat, Ceriumchlorid, Cäsiumchlorid mit geringerer Wirkungssteigerung; Thoriumnitrat, Zinkazetat und Aluminiumnitrat mit schwacher, unregelmäßiger Wirkung. Die Ursache für die Erregbarkeitssteigerung des Muskels durch gewisse Metallsalze konnte nicht geklärt werden. Wolpes Annahme einer Sensibilisierung durch Verdichtung der Zelloberfläche scheint nicht eine letzte Erklärung zu sein; denn einerseits teilen nicht alle Adstringentien mit Bleisalzen diese Eigenschaft, andererseits zeigen auch Nichtadstringentien (Physostigmin, Guanidin) erregbarkeitssteigernde Wirkung. Bei Vergleich der in Frage kommenden Metalle miteinander ließ sich irgendeine gemeinsame Eigenschaft nicht ausfindig machen, wie auch kein Parallelismus zwischen Erregbarkeitssteigerung und erregender Wirkung, Giftigkeit, Wertigkeit, chemischer Verwandtschaft, Atomgewicht oder dergleichen gefunden wurde. Die Erregbarkeitssteigerung der Muskulatur wird aufgefaßt als eine Sensibilisierung infolge Zustandsänderung der Muskelzelle, bedingt durch gewisse, in ihren Eigenschaften noch nicht näher charakterisierte Substanzen.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 224 (1977), S. 497-497 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 366 (1975), S. 75-85 
    ISSN: 1432-2307
    Keywords: Mitral Stenosis in Twins ; Mitral Valvotomy ; Mitral Valve Insufficiency ; Mitral Valve Prosthesis ; Local Thrombosis ; Malfunction of Prosthesis ; Combined Mitral Valve Disease ; Endocardial Fibroelastosis ; Pathological Anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit der vorliegenden Mitteilung wird u.W. erstmals eine isolierte kongenitale Mitralstenose bei einem Zwillingspaar — 7 Monate alt gewordener weiblicher Säugling (Zustand nach frischer, notfallmäßig ausgeführter Mitralvalvotomie), 2 9/12 Jahre alt gewordenes weibliches Kleinkind (Zustand nach prothetischem Mitralklappenersatz 6 Monate vor dem Tode) — beschrieben. Die pathologisch-anatomischen Befunde werden dokumentiert1 und diskutiert. Als Todesursache war bei dem einen Kinde ein Herzversagen nach operativ gesetzter Mitralklappeninsuffizienz anzunehmen, bei dem anderen Kinde ein Herzversagen infolge Ventildysfunktion. Das freie Klappenspiel des Björk-Shiley-Ventils, eines scharnierlosen Deckelventils, wurde mehr und mehr behindert durch einen zirkulär den Prothesenrand überwuchernden fibrösen Endokardwulst. Es resultierte eine Ventildysfunktion im Sinne eines kombinierten Mitralklappenfehlers. Schrittmacher der überschießenden Bindegewebs- und Endokardbildung dürfte eine lokale Gerinnselbildung im Prothesenlager und am Prothesen-ring gewesen sein, nachdem eine ausreichende Antikoagulantien-Applikation wegen post-operativer Serumhepatitis bei diesem Kinde nicht hatte betrieben werden können.
    Notes: Summary The pathoanatomical features of isolated congenital mitral stenosis in female twins are presented. At the age of 7 months one of the infants underwent an emergency mitral valvotomy and died the next day due to mitral insufficiency. A total mitral valvectomy and an implantation of a Björk-Shiley prosthesis were performed on the second child at the age of 27 months. Death occurred 6 months later due to malfunction of the prosthesis caused by a circular fibrous endocardial bulge on both the atrial and ventricular side of the prosthesis. The bulging endocardial fibrosis may have been favored by a local thrombosis, which was found circularly around the bed of the prosthesis after it was removed. Since the child suffered from postoperative serum hepatitis, anticoagulants could not be applied on a regular basis in sufficient doses. The relation of the endocardial fibroelastosis to the congenital valve disease and the implantation of a prosthesis is discussed. The site of the postoperative valve in the first child and the state of the second child after implantation of the mitral valve prosthesis are discussed in detail.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 368 (1975), S. 243-251 
    ISSN: 1432-2307
    Keywords: Kidney ; Myelomonocytic Leukemia ; Chronic Lymphocytic Leukemia ; Weights of Kidney, Liver, and Spleen and Leukemic Infiltration ; Hyperlysozymemia ; Hyaline Droplet Change ; Pathoanatomical Features
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kidneys of 18 autopsy cases of myelomonocytic leukemia (MML) were examined for MML-specific features. Nine cases of chronic lymphocytic leukemia (CLL) served as controls. The kidneys of the cases of MML showed macroscopically detectable sings of hemorrhagic diathesis and secondary uric acid diathesis more often than those of CLL. In the MML group most of the kidneys weighed more than the normal average for the corresponding age group, but the average renal weights for the 2 groups were about the same. Renal weight and grade of leukemic infiltration, particularly in MML, revealed no significant positive correlation. In most of the cases of MML there were unevenly distributed poorly defined leukemic, infiltrates in the renal cortex and medulla. The histology resembled that of pyelonephritis. In CLL, on the other hand, the leukemic infiltrates were usually sharply defined and localized in foci in the outer cortex and the corticomedullary border region. Renal dysfunction in cases of MML has been attributed by others to hyperlysozymemia. It was found occasionally but there was no MML-typical morphological substrate in our material. Hyaline droplet change of the tubular epithelium was more frequent and more pronounced in MML than in CLL. However, we also determined that it was nonspecific and that it was not a parameter of cell damage. Tubular hyaline droplet change and the morphological criteria of acute renal failure were not positively correlated with the degree of leukemic infiltration of the kidneys or with the leukemic proliferation as a whole. Instead, they were considered to be signs and symptoms of accompanying or secondary diseases which complicated the leukemia.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 369 (1975), S. 165-172 
    ISSN: 1432-2307
    Keywords: Mycosis fungoides ; Sézary syndrome ; Immunoblastic sarcoma ; Cytochemistry, Acid phosphatase ; Pathological anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 76 year old man with mycosis fungoides developed an immunoblastic sarcoma and a leukemic blood picture in the final tumor stage after 6 years, in which the disease had clinically progressed in a typical manner. The results of histological and cytochemical studies of autopsy material are presented. Based on these findings and evidence of the T cell nature of mycosis fungoides, the immunoblastic sarcoma observed in the terminal stage of this case of mycosis fungoides might be of the rare T cell type.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2307
    Keywords: Lymphogranulomatosis X ; (Angio)-immunoblastic lymphadenopathy ; Immunohistology ; Malignant transformation ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 172 cases of lymphogranulomatosis X (LgX) were studied by light microscopy. In 53 cases immunohistological techniques for detecting intracytoplasmic immunoglobulins were applied. In the lymph nodes of all cases the nodal architecture was found to be effaced. Active germinal centres were absent, and there was a generalized, markedly increased proliferation of epithelioid venules. A polymorphic infiltrate was present in all cases. It was dominated by immunoblasts in 14%, by plasma cells in 16%, by epithelioid cells in 23% and by lymphocytes in 6% of the cases. In the remaining 41% of the cases no special type of cell predominated (mixed cell type of LgX). The clusters of clear cells present in some cases with immunoblastic predominance did not stain for intracytoplasmic immunoglobulins; in contrast, the basophilic immunoblasts exhibited a polyclonal Ig pattern. In some of the cases with lymphocytic predominance most of the lymphocytes showed abundant cytoplasm with azurophil granules. Transformation into malignant lymphoma was proven at autopsy in 5 of 38 cases (13.2%). Malignant transformation (biopsy and autopsy material) was confirmed in a total of 11 of 172 cases (6.4%) and suspected in an additional 7%. Among the malignant lymphomas were one immunologically proven B-immunoblastic lymphoma, one peripheral T cell lymphoma and 5 cases of Hodgkin's disease. An association between LgX and carcinoma was histologically verified in 7 cases. 26 cases with active germinal centres and 11 cases with only locally pronounced vascularization but with histological and cytological changes that were otherwise similar to LgX were designated as hyperimmune reactions (HR). These cases had a significantly better prognosis. Two cases that presented as HR with active germinal centres later developed into LgX. It is suggested that the disappearance of active germinal centres is important in the pathogenesis of LgX. The possibility that this may correspond morphologically to an alteration of different components of the T-cell system is discussed.
    Type of Medium: Electronic Resource
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