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  • 1985-1989  (1)
  • 1975-1979  (1)
  • 1890-1899
  • Life and Medical Sciences  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of 86Rb+ and 32Pi movements in 3T3 cells by prostaglandins and phorbol esters (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 95 (1978), S. 287-294 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The potent tumor promoter tetradecanoyl phorbol acetate (TPA) induces early changes in ion movements analogous to those induced by prostaglandins E1 and F2α. Among the earliest changes induced by TPA is a significant increase in 32Pi incorporation within 15 minutes incubation of TPA (10-8-10-6 M) with post-confluent Swiss 3T3 mouse embryonic fibroblasts. Similarly, the active phorbol ester homolog 4-;β-;OH phorbol didecanoate but not the inactive stereoisomeric 4-β-OH phorbol didecanoate stimulated 32Pi incorporation. Also, TPA at the above concentrations stimulated 86Rb+ influx shortly after administration. Both fluxes were ouabain-sensitive in accord with the idea that an early effect of TPA is to alter (Na+ + K+)-ATPase activity. Further, prostaglandin E1 (10-7-10-6 M) and prostaglandin F2α (3 × 10-9-10-7 M) caused a similar stimulation of 86Rb+ and 32Pi uptake. The finding that water-soluble prostaglandin F2α also exhibited stimulatory effects indicated that those hormone-induced responses are not mediated by solvent interactions. The similar responses of phorbol esters and prostaglandin derivatives suggests that phorbol esters and prostaglandin derivatives may act at common membrane sitesThe finding that stimulatory effects were observed at discrete times in the logarithmic phase of growth suggests that the activation of membrane receptors may be cell-cycle dependent.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040950306
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Interactions of aged gametes: In vitro fertilization using in vitro-aged sperm and in vivo-aged ova in the mouse (1987)
    New York, NY : Wiley-Blackwell
    Gamete Research 16 (1987), S. 47-56 
    Details
    ISSN: 0148-7280
    Keywords: spermatozoa ; oocytes ; sperm penetration ; pronuclear stage ; prometaphase stage ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A study of varying combinations of in vitro-aged sperm and in vivo-aged ova at 3 hr intervals from 0-24 hr resulted in failures at different steps of the fertilization process during in vitro fertilization of mouse ova. Significant decreases caused by sperm aging, ova aging, and sperm × ova aging interaction were found in sperm penetration. Pronuclear formation was not affected by sperm aging and was enhanced by ova aging, and there was a significant effect of sperm × ova aging interaction. Sperm aging significantly influenced the prometaphase stage of the fertilization process. Therefore, it is suggested that the detrimental fertilization effects resulting from aging gametes are due to different mechanisms in sperm and ova, that these mechanisms are affected at different times, and that they affect different steps in the fertilization process.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120160106
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    Paper (German National Licenses)
    Fulltext
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