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  • 1985-1989  (2)
  • 1975-1979  (1)
  • 7q deletion  (1)
  • Development  (1)
  • Intermediate filament  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The development of spatial resolving power of lateral geniculate neurones in kittens (1978)
    Springer
    Experimental brain research 31 (1978), S. 193-206 
    Details
    ISSN: 1432-1106
    Keywords: Kitten LGN ; Development ; Visual acuity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spatial resolving power and receptive field properties of ‘sustained’ cells in layers A and A1 of the lateral geniculate nucleus (LGN), which received inputs from the area centralis of the retina in kittens of 3–16 weeks of age had been studied. The basic concentric organisation of receptive fields of ‘sustained’ LGN cells receiving inputs from the area centralis appeared to be already laid out at 3 weeks in kittens. Spatial resolving power of the cells determined using the highest spatial frequency of a sinusoidal grating resolved by cells as a measure of cellular visual acuity, however, developed gradually to the level of adult LGN cells during the sensitive period (3–12 weeks). Although this development occurred alongside the process of maturation of ocular alignment and the refractive state of the eyes, following the clearing of the embryonic vasculature of the ocular media from the 4th week onward, it depended on the enhancement of distinct inhibitory surround mechanisms taking place during the 6th–11th week. The course of development of spatial resolution of ‘sustained’ LGN cells receiving inputs from the area centralis of the retina runs parallel with the developmental curve of visual acuity in kittens obtained by visually evoked responses or by behavioural techniques by previous workers. The neural mechanisms which subserve high visual acuity are therefore already determined at the LGN before the inputs of the two eyes are mixed at the visual cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237599
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of Rathke's cleft cyst (1988)
    Springer
    Acta neuropathologica 77 (1988), S. 33-38 
    Details
    ISSN: 1432-0533
    Keywords: Rathke's cleft cyst ; Immunohistochemistry ; Pituitary hormones ; Intermediate filament ; Squamous metaplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study was made of ten cases of asymptomatic and three cases of symptomatic Rathke's cleft cyst. The cysts in the asymptomatic cases had monolayer columnar or cuboidal epithelium. Within the epithelium, cells which were positive for at least one of the pituitary hormones were found. The rate of positive reactions for these six pituitary hormones was between 70% and 100%. In contrast, the cysts in the symptomatic cases had an epithelium which was partly stratified squamous and partly squamous epithelium, and none of the pituitary hormones were found in them. Therefore, when a Rathke's cleft cyst enlarges to the extent that clinical symptoms are produced, we consider that changes have already occurred in structure and function of the cyst epithelium. In addition, we believe there is a tendency for monolayer epithelia to undergo squamous metaplasia and for cells which are positive for pituitary hormones to change into non-granulated cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688240
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A case of cebocephaly-holoprosencephaly with an aberrant adenohypophysis (1987)
    Springer
    Child's nervous system 3 (1987), S. 251-254 
    Details
    ISSN: 1433-0350
    Keywords: Holoprosencephaly ; Cebocephaly ; 7q deletion ; Aberrant adenohypophysis ; Multiple congenital anomalies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An autopsy case of cebocephaly-holoprosencephaly at 27 weeks' gestation is reported. Chromosome analysis revealed a 46, XX,-7, +der(7), t(7; 13) (q32; q34) pat karyotype. Pathological examination disclosed a hypoplastic aberrant adenohypohysis, in which immunohistochemical localization of four anterior pituitary hormones (ACTH, GH, PRL, TSH-β) was demonstrated. Malformation of the pituitary gland in holoprosencephaly can include ectopic adenohypophysis as well as pituitary dysgenesis, so a careful search for adenohypophysis should be made in future cases for a better understanding of endocrine dysgenesis associated with holoprosencephaly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274062
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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